研究業績achievements
永田研究室のこれまでの研究業績です
原著論文 2005年 - 2009
Y. Ishida & Kazuhiro Nagata
Autophagy eliminates a specific species of misfolded procollagen
and plays a protective role in cell survival against ER stress.
Autophagy5(8): 1217-1219(2009)
M. Ikeda, M. Naitoh, H. Kubota, T. Ishiko, K. Yoshikawa, S. Yamawaki, M.
Kurokawa, A. Utani, T. Nakamura, K. Nagata & S. Suzuki
Elastic fiber assembly is disrupted by excessive accumulation of chondroitin
sulfate in the human dermal fibrotic disease, keloid.
Biochem Biophys Res Commun.390:1221-1228(2009)
Y.Ishikawa, J.Wirz, J.A.Vranka, K.Nagata & H.P.B?chinger
Biochemical Characterization of the Prolyl 3-Hydroxylase 1oCartilage-associated
ProteinoCyclophilin B Complex
J. Biol. Chem.284(26): 17641-17647 (2009)
N. HOSOKAWA, Y. KAMIYA, D. KAMIYA, K. KATO & K. NAGATA
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated
degradation, recognizes mannose-trimmed N-Glycans.
J Biol Chem. 284 (25):17061-17068 (2009)
Y. ISHIDA, A. YAMAMOTO, A. KITAMURA, SR LAMANDE, T. YOSHIMORI, FB JOHN,
H.KUBOTA & K. NAGATA
Autophagic elimination of misfolded procollagen aggregates in the endoplasmic
reticulum as a means of cell protection.
Mol. Biol. Cell. 20 (11):2744-2754(2009)
N.HOSOKAWA & K.NAGATA
M-type lectins as novel components of secretory pathways.
In“ANIMAL LECTINS A Functional View”(Eds Gerardo R.Vasta, Hafiz Ahmed)
CRC Press pp.165-169(2009)
T. KAKUGAWA, S. YOKOTA, H. MUKAE, H. KUBOTA, N. SAKAMOTO,
S. MIZUNOE, Y. MATSUOKA, J. KADOTA, N. HUJII, K.NAGATA & S. KOHNO
High serum concentrations of autoantibodies to HSP47 in
nonspecific interstitial pneumonia compared with idiopathic
pulmonary fibrosis.
BMC Pulm Med. 8 (23):1-6(2008)
Y. ISHIKAWA, J. VRANKA, J. WIRZ, K. NAGATA & HP BACHINGER
The rough endoplasmic reticulum-resident FK506-binding protein
FKBP65 is a molecular chaperone that interacts with collagens.
J Biol Chem. 283 (46):31584-31590 (2008)
R.USHIODA, J.HOSEKI, K.ARAKI, G.JANSEN , D.Y.THOMAS, & K.NAGATA
ERdj5 is required as a disulfide reductase for degradation of
misfolded proteins in the ER.
Science 321 (5888):569-72(2008)
N.HOSOKAWA, I.WADA, K.NAGASAWA, T.MORIYAMA, K.OKAWA, & K.NAGATA
Human XTP3-B Forms an Endoplasmic Reticulum Quality Control
Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP.
J Biol Chem. 283 (30):20914-24(2008)
J.NAKAMURA, M.FUJIMOTO, K.YASUDA, K.TAKEDA, S.AKIRA, T.HATAYAMA,Y.TAKAGI,
K.NOZAKI, N.HOSOKAWA, & K.NAGATA
Targeted Disruption of Hsp110/105 Gene Protects against Ischemic Stres.
Ischemic Stress Stroke39:2853-2859(2008)
S.NAKAYAMA, H.MUKAE, N.SAKAMOTO, T.KAKUGAWA, S.YOSHIOKA, H.SODA,
H.OKU, Y.URATA, T.KONDO, H.KUBOTA, K.NAGATA & S.KOHNO
Pirfenidone inhibits the expression of HSP47 in TGF-beta1
-stimulated human lung fibroblasts.
Life Sci. 82 :210-217(2008)
D.MORITO, K.HIRAO, F.TOKUNAGA, N.HOSOKAWA, D.M. CYR, K.TANAKA,
K.IWAI & K.NAGATA
Gp78 cooperates with RMA1 in ER-associated degradation of
CFTRΔF508.
Mol. Biol. Cell. 19 :1328-1336(2008)
S.HIRAYAMA, Y.YAMAZAKI, A.KITAMURA, Y.ODA, D.MORITO, K.OKAWA,
H.KIMURA, D.M.CYR, H.KUBOTA & K.NAGATA
MKKS is a centrosome-shuttling protein degraded by disease
-causing mutations via CHIP-mediated ubiquitination.
Mol. Biol. Cell. 19 :899-911(2008)
N.HOSOKAWA, Z.YOU, L.O.TREMBLAY, K.NAGATA, A.HERSCOVICS
Stimulation of ERAD of misfolded null Hong Kong alfa-antitrypsin
by Golgi alfa1,2-mannosidases.
Biochem Biophys Res Commun. 362 :626-632(2007)
S.YOSHIOKA, H.MUKAE, H.ISHII, T.KAKUGAWA, H.ISHIMOTO, N.SAKAMOTO,
T.HUJII, Y.URATA, T.KONDO, H.KUBOTA, K.NAGATA, S.KOHNO
Alpha-defensin enhaces expression of HSP47 and collagen-1 in
human lung fibrolasts.
Life Sciences 80 :1839-1845(2007)
N.MIZOBUCHI, J.HOSEKI, H.KUBOTA, S.TOYOKUNI, J.NOZAKI, M.NAITOH,
A.KOIZUMI & K.NAGATA
ARMET is a soluble ER protein induced the unfolded protein
response via ERSE-II element.
Cell Srtuct. and Funct. 32 :41-50(2007)
K.NAGASAWA, T.HIGASHI, N.HOSOKWA, R.J. KAUFMAN & K.NAGATA
Simultaneous induction of the four subunits of TRAP complex by
ER stress accelerates ER degradation.
EMBO Rep.8 (5):483-490(2007)
A.OGURO , T.SAKURAI, Y.FUJITA, S.LEE, H.KUBOTA, K.NAGATA & Y.ATOMI
The molecular chaperone HSP47 rapidly senses gravitational
changes in myoblasts.
Genes Cells. 11 ,1253-1265(2006)
A. KITAMURA, H. KUBOTA, C. PACK, G.MATSUMOTO, S. HIRAYAMA,
Y. TAKAHASHI, H. KIMURA, M. KINJO, R. MORIMOTO & K. NAGATA
Cytosolic chaperonin prevents polyglutamine toxicity with altering
the aggregation state.
Nature Cell Biol. 8 (10):1163-1169(2006)
S. KUBOTA, H. KUBOTA & K. NAGATA
Cytosolic chaperonin protects folding intermediates of Gbeta from
aggregation by recognizing hydrophobic beta-strandsc.
Proc. Natl. Acad. Sci. USA, 103 (22):8360-8365(2006)
Y. ISHIDA, H. KUBOTA, A.YAMAMOTO, A. KITAMURA, H.P.BACHINGER
& K.NAGATA
Type I collagen in Hsp47-null cells is aggregated in ER and
deficient in N-propeptide processing and fibrillogenesis.
Mol. Biol. Cell. 17 :2346-2355(2006)
T,KOIDE, Y.NISHIKAWA, S.ASADA, C.M.YAMAZAKI, Y.TAKAHARA, DL.HOMMA,
A.OTAKA, N.WAKAMIYA, K.NAGATA & K.KITAGAWA
Specific recognition of the collagen triple helix by chaperone
HSP47.II. The HSP47-binding structural motif in collagens and
related proteins.
J. Biol. Chem. 281 (16):11177-11185(2006)
K.HIRAI, S.KIKUCHI, A.KURITA, S.OHASHI, E.ADACHI, Y.MATSUOKA, K.NAGATA
& M.WATANABE
Immunohistochemical distribution of heat shock protein 47
(HSP47) in scirrhous carcinoma of the stomach.
Anticancer Research 26 :71-78(2006)
N.HOSOKAWA, I.WADA, Y.NATSUKA & K.NAGATA
EDEM accelerates ERAD by preventing aberrant dimer formation
of misfolded alpha1-antitrypsin.
Genes Cells.11 (15)465-476(2006)
K.HIRAO, Y.NATSUKA, T.TAMURA, I.WADA, D.MORITO, S.NATSUKA, P.ROMERO,
B.SLENO, L.O.TREMBLAY, A.HERSCOVICS, K.NAGATA & N.HOSOKAW
EDEM3, a soluble EDEM homolog, enhances glycoprotein ERAD and
mannose trimming.
J. Biol. Chem. 281 (14):9650-9658(2006)
Y.ODA, T.OKADA, H. YOSHIDA, R.J.KAUFMAN, K.NAGATA & K.MORI
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
protein response and are required for ER-associated degradation.
J. Cell. Biol.172 (3):383-393(2006)
T,KOIDE, S.ASADA, Y.TAKAHARA, Y.NISHIKAWA, K.NAGATA & K.KITAGAWA
Specific recognition of the collagen triple helix by chaperone
HSP47.Minimal structural requirement and spatial molecular
orientation.
J. Biol. Chem.281 (6):3432-3438(2005)
F.KANO, H.KONDO, A.YAMAMOTO, Y.KANEKO, K.UCHIYAMA,N.HOSOKAWA,
K.NAGATA, M.MURATA
NSF/SNAPs and p97/p47/VCIP135 are sequentially required
for cell cycle-dependent reformation of the ER network.
Genes Cells.10 (10):989-999(2005)
T.YOSHINAGA, K.NAKATOME, J.NOZAKI, M.NAITOH, J.HOSEKI, H.KUBOTA,
K.NAGATA & A.KOIZUMI
Proinsulin lacking the A7-B7 disulfide bond, Ins2 Akita, tends
to aggregate due to the exposed hydrophobic surface.
Biol. Chem.386 (11):1077-1085(2005)
M.NAITOH, H.KUBOTA, M.IKEDA, T.TANAKA, H.SIRANE, S.SUZUKI & K.NAGATA
Gene expression in human keloids is altered from dermal to
chondrocytic and osteogenic lineage.
Genes Cells.10 (11):1081-1091(2005)
F.KANO, H.KONDO, A.YAMAMOTO, AR.TANAKA, N.HOSOKAWA, K.NAGATA, &M.MURATA.
The maintenance of the endoplasmic reticulum network is regulated by p47,
a cofactor of p97, through phosphorylation by cdc2 kinase.
Genes Cells. 10 (4):333-344(2005)
T.KOIDE & K.NAGATA
Collagen Biosynthesis.
Topics in Current Chemistry 247 :Collagen(EdsBrinckmann et al.)Springer-Verlag,
pp.85-114(2005)
