原著論文 2010年 - 2014年

D. Morito, K. Nishikawa, J. Hoseki, A Kitamura, Y. Kotani, K. Kiso, M. Kinjo, Y. Fujiyoshi & K. Nagata
Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state
Scientific Reports 24;4:4442(2014)

T. Kakugawa, S. Yokota, Y. Ishimatsu, T. Hayashi, S. Nakashima, S. Hara, N. Sakamoto, H. Kubota, M. Mine, Y. Matsuoka, H. Mukae, K. Nagata & S. Kohno
Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia
BMC Pulmonary Medicine 21;14:48(2014)

Y. Honzawa, H. Nakase, M. Shiokawa, T. Yoshino,H. Imaeda, M. Matsuura, Y. Kodama, H. Ikeuchi, A. Andoh, Y. Sakai,4 Kazuhiro Nagata,5 Tsutomu Chiba1
Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn’s disease
Gut 17(2014)

T. Ramming, H. G. Hansen, K. Nagata, L. Ellgaard, C. Appenzeller-Herzog
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
Free Radical Biol Med. 70:106-16(2014)

T. Olszak, J. F. Neves, C. M. Dowds, K. Baker, J. Glickman, N. O. Davidson, C-S. Lin, C. Jobin, S. Brand, K. Sotlar, K. Wada, K. Katayama, A. Nakajima, H. Mizuguchi, K. Kawasaki, K. Nagata, W. Muller, S.B. Snapper, S. Schreiber, A. Kaser, S. Zeissig & R. S. Blumberg
Protective mucosal immunity mediated by epithelial CD1d and IL-10
Nature 22;509(7501):497-502(2014)

A. Kitamura, N. Inada, H. Kubota, G. Matsumoto, M. Kinjo, R. I. Morimoto and K. Nagata
Dysregulation of the Proteasome Increases the Toxicity of ALS-linked Mutant SOD1
Genes Cells 19(3):209-24(2014)

T. Kakugawa, S. Yokota, Y. Ishimatsu, T. Hayashi, S. Nakashima, S. Hara, N. Sakamoto, Y. Matsuoka, H. Kubota, M. Mine, H. Mukae, K. Nagata & S. Kohno
Serum heat shock protein 47 levels in patients with drug-induced lung disease
Respiratory Research 14:133(2013)

R.Ushioda, J.Hoseki & K. Nagata
Glycosylation-independent ERAD pathway serves as a backup system under ER stress
Mol. Biol. Cell. 24(20):3155-3163(2013) DOI:10.1091/mbc.E13-03-0138

T. Kakihana, K. Araki, S. Vavassori, S. Iemura, M. Cortini, C. Fagioli, T. Natsume, R. Sitia & K. Nagata
Dynamic regulation of Ero1α and Prx4 localization in the secretory pathway
J. Biol. Chem. 288(41):29586-29594(2013) DOI: 10.1074/jbc.M113.467845

K.Araki, S.Iemura, Y.Kamiya, D.Ron, K.Kato, T. Natsume & K. Nagata
Ero1α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases
J. Cell. Biol. 202(6):861-874(2013)

T. Fujimori, Y. Kamiya, K. Nagata, K. Kato & N. Hosokawa
Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation
of a misfolded α1-antitrypsin variant.
FEBS J. doi: 10.1111/febs.12157(2013)

T. Kakugawa, S. Yokota, Y. Ishimatsu , T. Hayashi, S. Nakashima, S. Hara, N. Sakamoto, H. Kubota, M. Mine, Y. Matsuoka, H. Mukae, K. Nagata & S. Kohno
Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis.
Cell Stress and Chaperones 22 Feb(2013)

M. F. Abdul-Wahab, T. Homma, M. Wright, D. Olerenshaw,T. R. Dafforn, K. Nagata, A. D. Miller
The pH sensitivity of murine hsp47 binding to collagen is affected by mutations in the breach histidine cluster
J. Biol. Chem. 288(6):4452-4461(2013)

D.J. Klionsky, K.Nagata et al
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8(4):445-544(2012)

M.Yagi-Utsumi, S.Yoshikawa, Y.Yamaguchi, Y.Nishi, E.Kurimoto, Y.Ishida, T.Homma, J.Hoseki, Y.Nishikawa, T.Koide, K.Nagata and K. Kato
NMR and mutational identification of the collagen-binding site of the chaperone Hsp47.
PLoS ONE 7(9):e45930(2012)

K. Hisatomi, H. Mukae, N. Sakamoto, Y. Ishimatsu, T. Kakugawa, S. Hara, H. Fujita, S. Nakamichi, H. Oku, Y. Urata, H. Kubota, K. Nagata and S. Kohno
Pirfenidone inhibits TGF-beta1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells.
BMC Pulm Med. 12:24(2012)　

D. Morito and K. Nagata
ER stress proteins in autoimmune and inflammatory diseases.
Frontiers in Inflammation 3:48 (2012)

M. Hagiwara and K. Nagata
Redox-dependent protein quality control in the ER : folding to degrasation.
Antioxidants & Redox Signaling 　16(10):1119-1128(2012)

T. Kakihana, K.Nagata and R. Sitia
Peroxides and peroxidases in the endoplasmic reticulum : integrating redox homeostasis and oxidative folding.
Antioxidants & Redox Signaling 　16(8):763-771(2012)

T. Ono, T. Miyazaki, Y. Ishida, M. Uehata and K. Nagata
Direct in vitro and in vivo evidence for interaction between Hsp47 protein and collagen triple helix.
J. Biol. Chem. 287(9):6810-6818(2012)

Y.Masago, A.Hosoya, S.Kawano, A.Nasu, J.Toguchida, K.Fujita, H.Nakamura, G. Kondoh and K.Nagata
Molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation.
J. Cell Sci.　125(5):1118-1128(2012)

Y. Ishikawa, J. A. Vranka, S. P. Boudko, E. Pokidysheva, K. Mizuno, K. Zientek, D. R. Keene, A. M. Rashmir-Raven, K. Nagata, N. J. Winand and H. P. Bachinger.
The mutation in cyclophilin B that causes hyperelastosis cutis in the American Quarter Horse does not affect peptidyl-prolyl cis-trans isomerase activity, but shows altered cyclophilin B-protein interactions and affects collagen folding.
J. Biol. Chem 287(26):22253-65 (2012)

H. Kubota, A. Kitamura and K. Nagata.
Analyzing the aggregation of polyglutamine-expansion proteins and its modulation by molecular chaperones.
Methods53(3):267-274(2011)

K. Araki and K. Nagata.
Functional in vitro analysis of ERO1 and protein-disulfide isomerase (PDI) pathway.
J. Biol. Chem.286(37):32705-32712(2011)

W. Liu, D. Morito, S. Takashima, Y. Mineharu, H. Kobayashi, T. Hitomi, H. Hashikata, N. Matsuura, S. Yamazaki, A. Toyoda, K. Kikuta, Y. Takagi, K. H. Harada, A. Fujiyama, R. Herzig, B. Krischek, L. Zou, J.E. Kim, M. Kitakaze, S. Miyamoto, K. Nagata, N. Hashimoto and A. Koizumi.
Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development.
PLoS One. 2011;6(7):e22542. Epub 2011 Jul 20.

K. Araki and K. Nagata.
Protein Folding and Quality Control in the ER.
Cold Spring Harbor Perspectives in Biology3(11):a007526(2011)

N. Yamagishi, M. Yokota, K. Yasuda, Y. Saito, K. Nagata and T. Hatayama.
Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells.
Biochem Biophys Res Commun.409:90-95(2011)

Y. Ishida and K. Nagata.
Hsp47 as a collagen-specific molecular chaperone.
Methods Enzymol. 499:167-182(2011)

R. Ushioda and K. Nagata.
The endoplasmic reticulum-associated degradation and disulfide reductase ERdj5.
Methods Enzymol. 490:235-58 (2011)

Y. Iida, T. Fujimori, K. Okawa, K. Nagata, I. Wada and N. Hosokawa.
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.
J Biol Chem.286(19):16929-16939(2011)

M. Hagiwara, K. Maegawa, M. Suzuki, R. Ushioda, K. Araki, Y. Matsumoto, J. Hoseki, K. Nagata and K. Inaba
Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.
Mol Cell. 41(4):432-444(2011)

H. Kitamura, S. Yamamoto, H. Nakase, M. Matsuura, Y. Honzawa, K. Matsumura, Y. Takeda, N. Uza, K. Nagata and T. Chiba.
Role of heat shock protein 47 in intestinal fibrosis of experimental colitis.
Biochem Biophys Res Commun.404(2):599-604(2011)

D. Hasegawa, R. Fujii, N. Yagishita, N. Matsumoto, S. Aratani, T. Izumi, K. Azakami, M. Nakazawa, H. Fujita, T. Sato, N. Araya, J. Koike, M. Tadokoro, N. Suzuki, K. Nagata, H. Senoo, S. L. Friedman, K. Nishioka, Y. Yamano, F. Itoh and T. Nakajima.
E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis.
PLoS One 5(10):e13590(2010)

J. Hoseki, H. Sasakawa, Y. Yamaguchi,M. Maeda, H. Kubota, K. Kato and K. Nagata.
Solution structure and dynamics of mouse ARMET.
FEBS. Letters. 584(8):1536-1542. (2010)

Y. Sugiura, K.Araki, S. Iemura, T. Natsume, J. Hoseki and K. Nagata.
The novel thioredoxin-related transmembrane protein TMX4
has reductase activity.
J. Biol. Chem. 285(10):7135-7142 (2010)

Y. Honzawa , H. Nakase, Y. Takeda, K. Nagata and T. Chiba.
Heat shock protein 47 can be a new target molecule for intestinal fibrosis related to inflammatory bowel disease.
Inflammatory Bowel Diseases 16(12):2004-2006 (2010)

N. Hosokawa, L. O. Tremblay, B. Sleno, Y. Kamiya, I. Wada, K. Nagata, K. Kato
and A. Herscovics.
EDEM1 accelerates the trimming of α1,2-linked mannose on the C branch of N-glycans.
Glycobiology 20(5):567-575(2010)

J. Hoseki, R. Ushioda and K. Nagata.
Mechanism and components of endoplasmic reticulum-associated degradation.
Journal of Biochemistry 147(1):19-25(2010)

原著論文

2010年 - 2014年
2005年 - 2009年
2000年 - 2004年
1995年 - 1999年
1990年 - 1994年
1976年 - 1990年