研究業績achievements
永田研究室のこれまでの研究業績です
原著論文 1995年 - 1999年
M. TOMITA, K. YOSHIZATO, K. NAGATA & T. KITAJIMA
Enhancement of secretion of human procollagen I in mouse
HSP47-expressing insect cells.
J. Biochem. 126 (6):1118-1126 (1999)
H. HIRATA, I. YAMAMURA, K. YASUDA, A. KOBAYASHI, H. TADA, M. SUZUKI, K.
HIRAYOSHI, N. HOSOKAWA & K. NAGATA
Separate cis-acting DNA elements control cell type- and tissue-specific
expression of collagen-binding molecular chaperone HSP47.
J. Biol. Chem. 274 (50): 35703-35710 (1999)
T. KOIDE, S. ASADA & K. NAGATA
Substrate recognition of collagen-specific molecular chaperone
HSP47: Structural requirements and binding regulation.
J. Biol. Chem. 274 (49):34523-34526 (1999)
Y. KAWAZOE, M. TANABE, N. SASAI, K. NAGATA & A. NAKAI
HSF3 is a major heat shock responsive factor during chicken
embryonic development.
Eur.J. Biochem. 265 (2):688-697 (1999)
M. TANABE, N. SASAI, K. NAGATA, X-D. LIU, P. C. C. LIU, D. J. THIELE
& A. NAKAI.
The mammalian HSF4 gene generates both an activator and
a repressor of heat shock genes by alternative splicing.
J. Biol. Chem. 274 (39):27845-27856 (1999)
S. ASADA, T. KOIDE, H. YASUI & K. NAGATA
Effect of HSP47 on prolyl 4-hydroxylation of collagen model
peptides.
Cell Struct. Funct. 24 (4):187-196 (1999)
M. YOSHIDA, T. ENDO, K. ITO, N. HOSOKAWA & K.NAGATA
Dynamics and regulation of the stress response: Meeting report
on stress response and molecular chaperones at Kyoto.
Cell Stress & Chaperones. 4 (1):66-74 (1999)
N. NAGAI, T. YORIHUZI, N. HOSOKAWA & K.NAGATA
The human genome has a functional hsp47 gene (CBP2) and
pseudogene (pshsp47).
Gene. 227(2):241-248 (1999)
J. NISHIZAWA, A. NAKAI, K. MATSUDA, T. BAN & K. NAGATA
Reactive Oxygen Species Play an Important Role in the Activation
of Haet Shock Factor 1 in Ischemia-Reperfused Heart.
Circulation. 99(7):934-941 (1999)
J. NISHIZAWA & K. NAGATA
Regulation of heat shock transcription factors by hypoxia or
ischemia/reperfusion in the heart and brain.
Handbook of Experimental Pharmacology " Stress Proteins" Volume 136
(Ed. Latchman. D.S.) Springer-Verlag 1999., pp.201-224.
YOKOTA, S., YANAGI, H., YURA, T. AND KUBOTA, H.
Cytosolic chaperonin is up-regulated during cell growth:
preferential expression and binding to tubulin at G(1)/S transition
through early S phase.
J. Biol. Chem. 274, 37070-37078. (1999)
KUBOTA, H., YOKOTA, S., YANAGI, H. AND YURA, T.
Structures and co-regulated expression of the genes encoding
mouse cytosolic chaperonin CCT subunits.
Eur. J. Biochem. 262, 492-500. (1999)
KUBOTA, H., MATSUMOTO, S., YOKOTA, S., YANAGI, H. AND YURA, T.
Transcriptional activation of mouse cytosolic chaperonin CCT
subunit gene by heat shock factors HSF1 and HSF2.
FEBS Lett. 461, 125-129.(1999)
T. KOIDE & K. NAGATA
HSP47, A molecular chaperone which Interacts with procollagens
in the endoplasmic reticulum.
Connective Tissue.30(4):307-314 (1998)
N.YASUI, T.MORI, D.MORITO,O.MATSUSHITA, H.KOURAI, K.NAGATA, T.KOIDE
Dual-site recognition of different extracellular matrix components
by anti-angiogenic / neurotrophic serpin, PEDF.
Biochemistry.42 (11):3160-3167(2003)
H.MASUDA, N. HOSOKAWA & K. NAGATA
Expression and localization of collagen-binding stress protein
HSP47 in mouse embryo development : Comparison with types I
and II collagen.
Cell Stress & Chaperones. 3(4):256-264 (1998)
B. CAI, A. TOMIDA, K. MIKAMI, K. NAGATA & T. TSURUO
Down-Regulation of epidermal growth factor receptor-signaling
pathway by binding of GRP78/BiP to the receptor under glucose
-starved stress conditions.
J. Cell Physiol. 177:282-288 (1998)
Y. KAWAZOE, A. NAKAI, M. TANABE & K. NAGATA
Proteasome inhibition leads to the activation of all members of
the heat-shock-factor family.
Eur. J. Biochem. 255:356-362 (1998)
M. SUNAMOTO, K. KUZE, H. TSUJI, N. OHISHI, K. YAGI, K. NAGATA, T. KITA
& T. DOI
Antisense oligonucleotides against collagen-binding stress protein
HSP47 suppress collagen accumulation in experimental
glomerulonephritis.
Lab. Invest. 78(8):967-972 (1998)
N. HOSOKAWA, M. SATOH, C. HOHENADLE, K. Kuhn & K. NAGATA
HSP47, a collagen-specific molecular chaperone, delays the
secretion of type III procollagen transfected in human embryonic
kidney cell line 293.
A possible role for HSP47 in collagen modification.
J. Biochem. 124(3):654-662 (1998)
M.SUNAMOTO, K. KUZE, N. IEHARA, H. TAKEOKA, K. NAGATA, T. KITA & T. DOI
Expression of heat shock protein 47 is increased in remnant kindey
and correlates with disease progression.
Int J Exp Pathol. 79(3):133-140 (1998)
T. MORIYAMA, N. KAWADA, A. ANDO, A. YAMAUCHI, M. HORIO, K. NAGATA,
E. IMAI & M HORI
Up-regulation of HSP47 in the mouse kidneys with unilateral
ureteral obstruction.
Kidney Int. 54:110-119 (1998)
I.YAMAMURA, H. HIRATA, N. HOSOKAWA & K.NAGATA
Transcriptional activation of the mouse HSP47 gene in mouse
osteoblast MC3T3-E1 cells by TGF-beta1.
Biochem Biophys Res Commun. 244:68-74 (1998)
M. TANABE, Y. KAWAZOE, S. TAKEDA, R. I. MORIMOTO, K. NAGATA & A. NAKAI
Disruption of the HSF3 gene results in the severe reduction of
heat shock gene expression and loss of thermotolerance.
EMBO J. 17(6):1750-1758 (1998)
K. NAGATA, T. KOIDE, H. HIRATA, N. NAGAI, M. SATOH, N. HOSOKAWA
Role of molecular chaperone HSP47 in the synthesis and secretion
of procollagens.
THE 1996TANIGUCHI INTERNATIONAL SYMPOSIUM " From Molecules to Man
: Frontiers in Cell Biology ".(1997)
K.NAGATA
Expression and function of HSP47 : a collagen-specific molecular
chaperone in the endoplasmic reticulum.
Matrix Biology. 16:379-386 (1997)
T. MORIYAMA, N. KAWADA, Y. AKAGI, A. ANDO, M. HORIO, A. YAMAUCHI,
K.NAGATA, E. IMAI & M. HORI
TCV-116 inhibits interstitial fibrosis and HSP47 mRNA in rat
obstructive nephropathy.
Kidney Int. 52:232-235 (1997)
N. WATANABE, N. TSUJI, S. AKIYAMA, H. SASAKI, T. OKAMOTO,
D. KOBAYASHI, T. SATO, T. HAGINO, N. YAMAUCHI, Y. NIITSU, A. NAKAI
& K. NAGATA
Induction of heat shock protein 72 synthesis by endogenous tumor
necrosis factor via enhancement of the heat shock element
-binding activity of heat shock factor 1.
Eur. J. Immunol. 27:2830-2834 (1997)
T. NOGUCHI, K. CHIN, M. OHI, H. KITA, N. OTSUKA, T. TSUBOI, M. SATOH,
A. NAKAI, K. KUNO & K. NAGATA
Heat shock protein 72 level decreases during sleep in patients with
obstructive sleep apnea syndrome.
Am J Respir Crit Care Med. 155:1316-1322 (1997)
M. TANABE, A. NAKAI, Y. KAWAZOE, & K. NAGATA
Different thresholds in the responses of two heat shock
transcription facrors, HSF1 and HSF3.
J. Biol. Chem. 272:15389-15395 (1997)
D. WALSH, Z. LI, Y. WU, & K.NAGATA
Heat shock and the role of the HSPs during neural plate induction
in early mammalian CNS and brain development.
Cell Mol Life Sci. 53 (2):198-211 (1997)
K. NAGATA, M. SATOH, A.MILLER & N. HOSOKAWA
Involvement of HSP47 in the folding and processing of procollagen
in the endoplasmic reticulum.
Molecular Chaperones in Proteins; Structure, Function, and Mode of Action.
(Eds. Fink A L, Goto Y), Marcel Dekker, 1997, 10 pp.225-240
T. WAKAMIYA, R. TOGASHI, T. NISHIDA, K. SARUTA, J. YASUOKA,
S. KUSUMOTO, S. AIMOTO, K. Y. KUMAGAYE, K. NAKAJIMA & K.NAGATA
Synthetic study of phosphopeptides related to heat shock protein
HSP27.
Bioorg & Med Chem. 5 (1):135-145 (1997)
A. NAKAI, M. TANABE, Y. KAWAZOE, J. INAZAWA, R. I. MORIMOTO & K.NAGATA
HSF4, a new member of the human heat shock factor family which
lacks properties of a transcriptional activator.
Mol. Cell. Biol. 17 (1):469-481 (1997)
KUBOTA, H., HYNES, G. M., KERR, S. M., AND WILLISON, K. R.
Tissue-specific subunit of the mouse cytosolic chaperonin
-containing TCP-1.
FEBS Lett. 402, 53-56. (1997)
Y. TANAKA, K. KOBAYASHI, M. KITA, H. MASUDA, S. KINOSHITA, K. NAGATA,
J . IMANISHI
Expression of 47 kDa heat shock protein (HSP47) during
development of mouse cornea.
Exp Eye Res 63: 383-393 (1996)
K. NAGATA & N.HOSOKAWA
Regulation and function of collagen-specific molecular chaperone,
HSP47.
Cell Structure and Function. (Dynamics of the Cell) 21(5):425-430 (1996)
J. NISHIZAWA, A. NAKAI, T. HIGASHI, M. TANABE, S. NOMOTO, K. MATSUDA,
T. BAN & K. NAGATA
Reperfusion causes significant activation of heat shock
transcription factor 1 in ischemic rat heart.
Circulation. 94 (9):2185-2192 (1996)
K. NAGATA
Regulation of thermotolerance and ischemic tolerance.
Stress-Inducible Cellular Responses (Eds.U. Feige, R. I. Morimoto, I. Yahara, B.S. Polla ),
Birkhauser, 1996, pp. 467-481.
N. KAWADA, T. KUROKI, K. KOBAYASHI, M. INOUE, K. NAKATANI, K. KANEDA
& K. NAGATA
Expression of heat-shock protein 47 in mouse liver.
Cell Tissue Res. 284:341-346 (1996)
M. SATOH, K. HIRAYOSHI, S. YOKOTA, N. HOSOKAWA & K. NAGATA
Intracellular interaction of collagen-specific stress protein HSP47
with newly synthesized procollagen.
J. Cell Biol. 133(2):469-483 (1996)
T. S. H. EL-THAHER, A. F. DRAKE, S. YOKOTA, A. NAKAI, K. NAGATA
& A. D. MILLER
The pH-dependent, ATP-independent interaction of collagen
specific serpin/stress protein HSP47.
Prot Pept Lett.3 (1):1-8 (1996)
K. NAGATA
HSP47: a collagen-specific molecular chaperone in the
endoplasmic reticulum.
TiBS.(Trends in Biochemical Sciences)21(1):22-26 (1996)
J.Yun, A.Tomida, K.Nagata & T.Tsuruo
Glucose-regulated stresses confer resistance to VP-16 in
human cancer cells through a decreased expression of DNA
topoisomerase II.
Oncology Research. 7(12):583-590 (1995)
J.W.Davids, T.S.H.El-Thaher, A.Nakai, K.Nagata & A.D.Miller
Modeling the three-dimensional structure of serpin/molecular
chaperone HSP47.
Bioorganic Chemistry. 23:427-438 (1995)
K.Yasuda, A.Nakai, T.Hatayama & K.Nagata
Cloning and expression of murine high-molecular-wight heat shock
proteins, HSP105.
J. Biol. Chem. 270(50):29718-29723 (1995)
N.Nakamura, M.Shida, K.Hirayoshi & K.Nagata
Transcriptional regulation of the vimentin-encoding gene in mouse
myeloid leukemia M1 cells.
Gene. 166:281-286 (1995)
A.Nakai, Y.Kawazoe, M.Tanabe, K.Nagata & R.I.Morimoto
The DNA-Binding properties of two heat shock factors, HSF1 and
HSF3, are induced in the avian erythroblast cell line HD6.
Mol. Cell. Biol. 15(10):5268-5278 (1995)
T.Higashi, A.Nakai, Y.Umeda, H.Kikuchi & K.Nagata
Activation of heat shock factor 1 in rat brain during cerebral
ischemia or after heat shock.
Mol. Brain Res. 34:262-270 (1995)
T.Higashi, S.Nishi, A.Nakai & K.Nagata
Regulatory mechanism of stress response in mammalian nervous
system during cerebral ischemia or after heat shock.
Neuropathology and Applied Neurobiology. 21:480-483 (1995)
N.Nagai, A.Nakai & K.Nagata
Quercetin suppresses heat shock response by down regulation
of HSF1.
Biochem. Biophys. Res. Commun. 208(3):1099-1105 (1995)
A.Nakai, T.Kawatani, S.Ohi, H.Kawasaki, T.Yoshimori, Y.Tashiro, Y.Miyata, I.Yahara,
M.Satoh & K.Nagata
Expression and phosphorylation of BiP/GRP78, a molecular
chaperone in the endoplasmic reticulum, during the differentiation
of a mouse myeloblastic cell line.
Cell Struct. Funct. 20:33-39 (1995)
