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研究業績achievements

永田研究室のこれまでの研究業績です

原著論文 1995年 - 2000

H.KUBOTA & K.NAGATA
Roles of collagen fibers and its specific molecular chaperone: analysis using HSP47-knockout mice.
Biol Sci Space.18 (3):118-119(2004)

S.J.MARCINIAK, C.Y.YUN, S.OYADOMARI, I.NOVOA, Y.ZHANG, R.JUNGREIS,
K.NAGATA,H.P.HARDING & D.RON
CHOP induces death by promoting protein synthesis and oxidation
in thestressed endoplasmic reticulum.
Genes Develop.18 (24):3066-3077(2004)

T.MARUTANI, A.YAMAMOTO, N.NAGAI, H.KUBOTA & K.NAGATA
Accumulation of type IV collagen in dilated endoplasmic reticulum
leads to apoptosis HSP47-knockout mouse embryos through the
induction of CHOP.
J.Cell.Sci.117 :5913-5922(2004)

M.YAMASHITA, K.HIRAYOSHI & K.NAGATA
Characterization of multiple members of the HSP70 family in
platyfishculture cells: molecular evolution of stress protein HSP70
in vertebrates.
Gene 336 :207-218(2004)

Y.MATSUOKA, H.KUBOTA, E.ADACHI, N.NAGAI, T.MARUTANI, N.HOSOKAWA
& K.NAGATA
Insufficient folding of type IV collagen nad formation of abnormal
basement membrane-like structure in embryoid bodies derived
from HSP47-null ES cells.
Mol. Biol. Cell.15 :4467-4475 (2004)

S.OHASHI, H.ABE, T.TAKAHASHI, Y.YAMAMOTO, M.TAKEUCHI, H.ARAI,
K.NAGATA, T.KITA, H.OKAMOTO, H.YAMAMOTO, T.DOI
Advanced glycation end products increase collagen-specific
chaperone protein in mouse diabetic nephropathy.
J. Biol. Chem.279 (19):19816-19823(2004)

J.NOZAKI, H.KUBOTA, H.YOSHIDA, M.NAITOH, J.GOJO, T.YOSHINAGA,
K.MORI, A.KOIZUMI & K.NAGATA
The endoplasmic reticulum stress response is stimulated through
the continuous activation of transcription factors ATF6 and XBP1
in Ins2+/Akita pancreatic beta cells.
Genes Cells9 :261-270(2004)

K.NAGATA
HSP47 as a collagen-specific molecular chaperone:function and
expression in normal mouse development.
Seminars in Cell and Developmental Biology 14:275-282 (2003)

Y.YAMAZAKI, H.KUBOTA, M.NOZAKI & K.NAGATA
Transcriptional regulation of the cytosolic chaperonin theta
subunit gene, Cctq, by Ets domain transcription factors Elk-1,
Sap-1a, and Net in the absence of serum response factor.
J. Biol. Chem.278 (33):30642-30651 (2003)

N.HOSOKAWA, L.O.TREMBLAY, Z.YOU, A.HERSCOVICS, I,WADA & K.NAGATA
Enhancement of endoplasmic reticulum (ER) degradation of
misfolded Null Hong Kong alpha1-antitrypsin by human ER
mannosidase I.
J. Biol. Chem.278 (28):26287-26294(2003)

J.NAKAMURA, M.FUJIMOTO, K.YASUDA, K.TAKEDA, S.AKIRA, T.HATAYAMA,Y.TAKAGI, K.NOZAKI, N.HOSOKAWA, & K.NAGATA
Targeted Disruption of Hsp110/105 Gene Protects against Ischemic Stres.
Ischemic Stress Stroke39:2853-2859(2008)

S.YOKOTA, H.KUBOTA, Y.MATSUOKA, M.NAITOH, D.HIRATA, S.MINOTA,
H.TAKAHASHI, N.FUJII & K.NAGATA
Prevalence of HSP47 antigen and autoantibodies to HSP47 in
the sera of patients with mixed connective tissue disease.
Biochem Biophys Res Commun.303 :413-418(2003)

Y.ODA, N.HOSOKAWA,I .WADA & K.NAGATA
EDEM as an acceptor of terminally misfolded glycoproteins
released from calnexin.
Science299 (5611):1394-1397(2003)

H.YOSHIDA, T.MATSUI, N.HOSOKAWA, R.J.KAUFMAN, K.NAGATA & K.MORI
A.time-dependent phase shift in the mammalian unfolded proten
response.
Develop. Cell. 4 (2):265-271(2003)

N.YASUI, T.MORI, D.MORITO,O.MATSUSHITA, H.KOURAI, K.NAGATA, T.KOIDE
Dual-site recognition of different extracellular matrix components
by anti-angiogenic / neurotrophic serpin, PEDF.
Biochemistry.42 (11):3160-3167(2003)

K.YASUDA, K.HIRAYOSHI, H.HIRATA, H.KUBOTA, N.HOSOKAWA & K.NAGATA
The Kruppel-like factor Zf9 and proteins in the Sp1 family
regulate the expression of HSP47, a collagen-specific molecular.
J. Biol Chem.277 (47):44613-44622(2002)

K.SATO, K.YOMOGIDA, T.WADA, T.YORIHUZI, Y.NISHIMUNE, N.HOSOKAWA
&K.NAGATA
Type XXVI collagen, a new member of the collagen family,
is specifically expressed in the testis and ovary.
J. Biol Chem.277 (40):37678-37684(2002)

N.HOSOKAWA & K.NAGATA
α-mannosidase-like protein involved in quality control in
the endoplasmic reticulum(ER).
Glycoforum websiteモBeyond glycogens (Ed. N.Taniguchi) Seikagaku Corporation,6(2002)

J.NISHIZAWA,A.NAKAI,M.KOMEDA,T.BAN & K.NAGATA
Increased preload directly induces the activation of heat shock
transcription factor 1 in the left ventricular overloaded heart.
Cardiovas. Res.55 (2):341-348(2002)

T.KOIDE,Y.TAKAHARA,S.ASADA & K.NAGATA
Xaa-Arg-Gly triplets in the collagen triple-helix are dominant
binding sites for the molecular chaperone HSP47.
J. Biol. Chem.277 (8):6178-6182(2002)

T. KOIDE,Y.TAKAHASHI,S.ASADA, K. NAGATA & Y.ITO 
Substrate recognition of collagen-specific molecular chaperone
HSP47:contribution of arginine residue in the triple helical
substrates.
Peptide Science2000 (Ed.T. Shioiri)The Japanese Peptide Society, pp.159-162(2001)

N. HOSOKAWA & K. NAGATA
Procollagen binding to both prolyl 4-hydroxylase/protein disulfide
isomerase and HSP47 within the endoplasmic reticulum in the
absence of ascorbate.
FEBS. Letters.466 (1):19-25 (2000)

J. NISHIZAWA & K. NAGATA
Ischemia/reperfusion injury and heat shock proteins.
" Heat Shock Proteins in Myocardial protection" Medial IntelligenceUnit16
Landes Bioscience. pp.121-134(2000)

・K.ABE, Y.OZONO, M.MIYAZAKI, T.KOJI, K.SHIOSHITA, A.FURUSU,
S.TSUKASAKI, F.MATSUYA, N.HOSOKAWA, T.HIRADA, T.TAGUCHI, K.NAGATA
& S.KOHNO
Interstitial expression of heat shock protein 47 and alpha-smooth
muscle actin in renal allograft failure.
Nephrol Dial Transplant 15 (4):529-535(2000)

KUBOTA, H., YOKOTA, S., YANAGI, H. AND YURA, T.
Transcriptional regulation of the mouse cytosolic chaperonin
subunit gene Ccta/t-conplex polypeptide 1 by selenocysteine
tRNA subunit gene transcription factor family zinc finger proteins.
J. Biol. Chem.275 , 28641-28648. (2000)

YOKOTA, S., YANAGI, H., YURA, T. AND KUBOTA, H.
Upregulation of cytosolic chaperonin CCT subunits during recovery
from chemical stress that causes accumulation of unfolded
proteins.
Eur. J. Biochem.267, 1658-1664. (2000)

YOKOTA, S., HIRATA, D., MINOTA, S., HIGASHIYAMA, T., KURIMOTO, M.,
YANAGI, H., YURA, T. & KUBOTA, H.
Autoantibodies against cytosolic chaperonin CCT in human sera
with rheumatic autoimmune diseases: comparison with antibodies
against other HSP60 family proteins.
Cell Stress Chaperones5, 337-346. (2000)

YOKOTA, S., KAYANO, T., OHTA T., KURIMOTO, M., YANAGI, H., YURA, T. & KUBOTA, H.
Proteasome-dependent degradation of cytosolic chaperonin CCT.
Biochem. Biophys. Res. Commun.279, 712-717. (2000)

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