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Publication

• Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y: ANGPTL2 expression in the intestinal stem cell niche controls epithelial regenerationand homeostasis. EMBO J. 36: 409-424, 2017
• Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K: DNase II-dependent DNA digestion is required for DNA sensing by TLR9 degradation. Nat Commun. 6: 5853, 2015
• Kawane K, Nagata S : DNA degradation and its defects. Cold Spring Harb Perspect Biol, 2014
• Nagata S, Kawane K : Autoinflammation by endogenous DNA. Adv Immunol. 110: 139-61, 2011
• Kawane K, Tanaka H, Kitahara Y, Shimaoka S, Nagata S : Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A. 107: 19432-7, 2010
• Kitahara Y, Kawane K, Nagata S : Interferon-induced TRAIL-independent cell death in DNase II-/- embryos. Eur J Immunol. 40: 2590-8, 2010
• Ostberg T, Kawane K, Nagata S, Yang H, Chavan S, Klevenvall L, Bianchi ME, Harris HE, Andersson U, Palmblad K : Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model. Arthritis Rheum. 62: 2963-72, 2010
• Nagata S, Hanayama R, Kawane K : Autoimmunity and the clearance of dead cells. Cell. 140: 619-30, 2010
• Nagasaka A, Kawane K, Yoshida H, Nagata S : Apaf-1-independent programmed cell death in mouse development. Cell Death Differ. 17: 931-41, 2010
• Kawane K : Molecular mechanisms and physiological roles of DNA degradation. Seikagaku. 81: 765-79, 2009
• Okabe Y, Kawane K, Nagata S : IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol. 38: 3150-8, 2008
• Kawane K, and Nagata S : Nucleases in Programmed Cell Death. Methods Enzymol. 442: 271-87, 2008
• Nakahara M., Nagasaka A, Koike M, Uchida K., Kawane K, Uchiyama Y, Nagata S : Degradation of nuclear DNA by DNase II-like Acid DNase in cortical fiber cells of mouse eye lens. FEBS J. 274: 3055-64, 2007
• Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, Yoshikawa H, Nagata S : Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature. 443: 998-1002, 2006
• Bergsmedh A, Ehnfors J, Kawane K. Motoyama N, Nagata S, Holmgren L : DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA. Mol Cancer Res. 4: 187-95, 2006
• Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S : Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med. 202: 1333-9, 2005
• Yoshida H, Kawane K, Koike M, Mori Y, Uchiyama Y, Nagata S : Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature. 437: 754-8, 2005
• Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S : Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol. 6: 49-56, 2005
• Nishimoto S, Kawane K, Watanabe-Fukunaga R, Fukuyama H, Ohsawa Y, Uchiyama, Y, Hashida N, Ohguro N, Tano Y, Morimoto T, Fukuda Y, Nagata S : Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature. 424: 1071-4, 2003
• Kawane K, Fukuyama H, Yoshida H, Nagase H, Ohsawa Y. Uchiyama Y, Okada K, Iida T, Nagata S : Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol. 4: 138-144, 2003
• Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H : Degradation of chromosomal DNA during apoptosis. Cell Death Differ. 10: 108-116, 2003
• Nagase H, Fukuyama H, Tanaka M, Kawane K Nagata S : Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ. 10: 142-3, 2003
• Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y, Nagata S : Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science. 292: 1546-9, 2001
• Kawane K, Fukuyama H, Adachi M, Sakahira H, Copeland NG, Gilbert DJ, Jenkins NA, Nagata S : Structure and promoter analysis of murine CAD and ICAD genes. Cell Death Differ. 6: 745-52, 1999
• Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y: ANGPTL2 expression in the intestinal stem cell niche controls epithelial regenerationand homeostasis. EMBO J. 36: 409-424, 2017