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論文

-- 2021 --

Yamada, T. & Tsuge, H.
Preparation of Clostridium perfringens binary iota-toxin pore complex for structural analysis using cryo-EM.
Method Enzymol 649:125-148.

-- 2020 --

Yoshida T. & Tsuge, H.
Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases.
Toxins(Basel) 13(1):40

Tsuge, H.
A myelin sheath protein forming its lattice J Biol Chem 295(26):8706-8707.

Yamada T, Yoshida T, Kawamoto A, Mitsuoka K, Iwasaki K, & Tsuge H.
Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex.
Nat Struct & Mol Biol. 27(3):288-296. (2020)

-- 2018 --

Yoshida T. & Tsuge, H.
Substrate N2 atom recognition mechanism in pierisin family DNA-targeting, guanine-specific ADP-ribosyltransferase ScARP.
J. Biol. Chem. 293, 13768-13774 (2018)

Suzuki Y., Tsuge H., Hondoh H., Kato Y., Uehara Y., Maita N., Hosokawa K., & Ueta S.
Precipitant-Free Lysozyme Crystals Grown by Centrifugal Concentration Reveal Structural Changes.
Crystal Growth and Design 18(8), 4226-4229

-- 2017 --

Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, Okamoto K, Yoshida T, Tsuge H, & Yamanaka H.
Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity.
PLoS ONE 12, e0186392 (2017)

Toniti, W., Yoshida, T., Tsurumura, T., Irikura, D., Monma, C., Kamata, Y., & Tsuge, H.
Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin.
PLoS ONE 12, e0171278 (2017)

Tsuge, H., Tsurumura, T., Toda, A., Murata, H., Toniti, W., & Yoshida, T.
Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology.
Curr. Top. Microbiol. Immunol. 399, 69-86 (2017)

-- 2016 --

Toda, A., Tsurumura, T., Yoshida, T., Tsumori, Y., & Tsuge, H.
Structural Basis of Rho GTPase Recognition by C3 Exoenzyme.
Photon Factory Highlights 2015 58-59 (2016)

Yoshida, T., Ogola, H. J. O., Amano, Y., Hisabori, T., Ashida, H., Sawa, Y., Tsuge, H., & Sugano, Y.
Anabaena sp.DyP-type peroxidase is a tetramer consisting of two asymmetric dimers.
Proteins 84, 31-42 (2016)

-- 2015 --

Tsuge, H., Yoshida, T., & Tsurumura, T.
Conformational plasticity is crucial for C3-RhoA complex formation by ARTT-loop.
Pathog. Dis. 73, ftv094 (2015)

Toda, A., Tsurumura, T., Yoshida, T., Tsumori, Y., & Tsuge, H.
Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure.
J. Biol. Chem. 290, 19423-19432 (2015)

Kobayashi, H., Yoshida, T., Miyakawa, T., Tashiro, M., Okamoto, K., Yamanaka, H., Tanokura, M., & Tsuge, H.
Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria.
J. Biol. Chem. 290, 11130-11143 (2015)

Tsuge, H. & Tsurumura, T.
Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein.
Curr. Top. Microbiol. Immunol. 384, 69-87 (2015).

-- 2014 --

Tsurumura, T. & Tsuge, H.
Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure.
J. Struct. Funct. Genomics 15, 83-89 (2014).

Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y. & Tsuge, H.
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.
Acta Cryst. F 70, 72-75 (2014).

-- 2013 --

Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y., Hatakeyama, D., Kuzuhara, T., & Tsuge, H.
Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.
PLoS ONE 8, e82020 (2013).

Tsurumura, T., Tsumori, Y., Qiu, H., Oda, M., Sakurai, J., Nagahama, M., & Tsuge, H.
Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex.
Proc. Natl. Acad. Sci. U.S.A. 110, 4267-4272 (2013).

-- 2012 --

Kuzuhara, T. & Tsuge, H.
The tertiary structures of the domains of influenza RNA polymerase.
Seikagaku 84, 780-785 (2012).

Yoshida, T., Tsuge, H., Hisabori, T. & Sugano, Y.
Crystal structures of dye-decolorizing peroxidase with ascorbic acid and 2,6-dimethoxyphenol.
FEBS Lett. 586, 4351-4356 (2012).

Oda, M., Hashimoto, M., Takahashi, M., Ohmae, Y., Seike, S., Kato, R., Fujita, A., Tsuge, H., Nagahama, M., Ochi, S., Sasahara, T., Hayashi, S., Hirai, Y., & Sakurai, J.
Role of sphingomyelinase in infectious diseases caused by Bacillus cereus.
PLoS ONE 7, e38054 (2012).

Oda, M., Takahashi, M., Tsuge, H., Nagahama, M. & Sakurai, J.
Role of side-edge site of sphingomyelinase from Bacillus cereus.
Biochem. Biophys. Res. Commun. 422, 128-132 (2012).

-- 2011 --

Imagawa, T., Tsurumura, T., Sugimoto, Y., Aki, K., Ishidoh, K., Kuramitsu, S., & Tsuge, H.
Structural basis of free reduced flavin generation by flavin reductase from Thermus thermophilus HB8.
J. Biol. Chem. 286, 44078-44085 (2011).

Ohtomo, H., Konuma, T., Utsunoiya, H., Tsuge, H. & Ikeguchi, M.
Structure and stability of Gyuba, a β-lactoglobulin chimera.
Protein Sci. 20, 1867-1875 (2011).

Yoshida, T., Tsuge, H., Konno, H., Hisabori, T. & Sugano, Y.
The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue.
FEBS J. 278, 2387-2394 (2011).

-- 2010 --

Watanabe, T., Tsuge, H., Imagawa, T., Kise, D., Hirano, K., Beppu, M., Takahashi, A., Yamaguchi, K., Fujiki, H., & Suganuma, M.
Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori.
J. Cancer Res. Clin. Oncol. 136, 911-921 (2010).

-- 2009 --

Kobayashi, H., Tateishi, A., Tsuge, H., Takahashi, E., Okamoto, K., & Yamanaka, H.
The carboxy-terminal tail of Aeromonas sobria Serine Protease is associated with the chaperone.
Microbiol. Immunol. 53, 647-657 (2009).

Sakurai, J., Nagahama, M., Oda, M., Tsuge, H. & Kobayashi, K.
Clostridium perfringens iota-toxin: structure and function.
Toxins (Basel) 1, 208-228 (2009).

Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K., & Tsuge, H.
Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.
J. Biol. Chem. 284, 27655-27663 (2009).

Tsuge, H., Tsurumura, T., Utsunomiya, H., Kise, D., Kuzuhara, T., Watanabe, T., Fujiki, H., & Suganuma, M.
Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.
Biochem. Biophys. Res. Commun. 388, 193-198 (2009).

Kawakami, R., Sakuraba, H., Goda, S., Tsuge, H. & Ohshima, T.
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.
Biochim. Biophys. Acta 1794, 1496-1504 (2009).

Kuzuhara, T., Kise, D., Yoshida, H., Horita, T., Murazaki, Y., Utsunomiya, H., & Tsuge, H.
Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2.
Acta Cryst. F 65, 144-146 (2009)

Kuzuhara, T., Kise, D., Yoshida, H., Horita, T., Murazaki, Y., Nishimura, A., Echigo, N., Utsunomiya, H., & Tsuge, H.
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue.
J. Biol. Chem. 284, 6855-6860 (2009).

Tsukamoto, S., Yamashita, T., Yamada, Y., Fujiwara, K., Maki, K., Kuwajima, K., Matsumura, Y., Kihara, H., Tsuge, H., & Ikeguchi, M.
Non-native alpha-helix formation is not necessary for folding of lipocalin: comparison of burst-phase folding between tear lipocalin and beta-lactoglobulin.
Proteins 76, 226-236 (2009).

Nakaishi, Y., Bando, M., Shimizu, H., Watanabe, K., Goto, F., Tsuge, H., Kondo, K., & Komatsu, M.
Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes.
FEBS Lett. 583, 163-167 (2009).

-- 2008 --

Sakuraba, H., Yoneda, K., Takeuchi, K., Tsuge, H., Katunuma, N., & Ohshima, T.
Structure of an archaeal alanine:glyoxylate aminotransferase.
Acta Cryst. D 64, 696-699 (2008).

Tsuge, H., Nagahama, M., Oda, M., Iwamoto, S., Utsunomiya, H., Marquez, V. E., Katunuma, N., Nishizawa, M., & Sakurai, J.
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin.
Proc. Natl. Acad. Sci. U.S.A. 105, 7399-7404 (2008).

Sakuraba, H., Yoneda, K., Asai, I., Tsuge, H., Katunuma, N., & Ohshima, T.
Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii.
Biochim. Biophys. Acta. 1784, 563-571 (2008)

Imagawa, T., Iino, H., Kanagawa, M., Ebihara, A., Kuramitsu, S., & Tsuge, H.
Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase.
Biochem. Biophys. Res. Commun. 367, 535-541 (2008)

-- 2007 --

Kawazoe, T., Park, H. K., Iwana, S., Tsuge, H., & Fukui, K.
Human D-amino acid oxidase: an update and review.
Chem. Rec. 7, 305-315 (2007)

Sakuraba, H., Yoneda, K., Yoshihara, K., Satoh, K., Kawakami, R., Uto, Y., Tsuge, H., Takahashi, K., Hori, H., & Ohshima, T.
Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase.
Appl. Environ. Microbiol. 73, 7427-7434 (2007)

Yoneda, K., Sakuraba, H., Tsuge, H., Katunuma, N., & Ohshima, T.
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.
FEBS J. 274, 4315-4325 (2007)

Kawazoe, T., Tsuge, H., Imagawa, T., Aki, K., Kuramitsu, S., & Fukui, K.
Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis.
Biochem. Biophys. Res. Commun. 355, 385-391 (2007)

Nakayama, H., Shimamura, T., Imagawa, T., Shirai, N., Itoh, T., Sako, Y., Miyano, M., Sakuraba, H., Ohshima, T., Nomura, N., & Tsuge, H.
Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability.
J. Mol. Biol. 365, 362-378 (2007)

-- 2006 --

Kawazoe, T., Tsuge, H., Pilone, M. S., & Fukui, K.
Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring.
Protein Sci. 15, 2708-2717 (2006)

Ago, H., Oda, M., Takahashi, M., Tsuge, H., Ochi, S., Katunuma, N., Miyano, M., & Sakurai, J.
Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus.
J. Biol. Chem. 281, 16157-16167 (2006)

Tsuge, H., Aki, K., Katanuma, N., Kawakami, R., Sakuraba, H., & Ohshima, T.
Novel diflavin-containing dehydrogenase family: FAD, FMN and ATP-containing L-proline dehydrogenase.
Seikagaku 78, 41-45 (2006)

-- 2005 --

Yoneda, K., Sakuraba, H., Tsuge, H., Katunuma, N., Kuramitsu, S., Kawabata, T., & Ohshima, T.
The first crystal structure of an archaeal helical repeat protein.
Acta Cryst. F 61, 636-639 (2005)

Kuzuhara, T., Suganuma, M., Tsuge, H., & Fujiki, H.
Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins.
Biol. Pharm. Bull. 28, 2133-2137 (2005)

Kawakami, R., Sakuraba, H., Tsuge, H., Goda, S., Katunuma, N., & Ohshima, T.
A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3.
FEBS J. 272, 4044-4054 (2005)

Tsuge, H., Kawakami, R., Sakuraba, H., Ago, H., Miyano, M., Aki, K., Katunuma, N., & Ohshima, T.
Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii.
J. Biol. Chem. 280, 31045-31049 (2005)

Sakuraba, H., Tsuge, H., Yoneda, K., Katunuma, N., & Ohshima, T.
Crystal structure of the NAD biosynthetic enzyme quinolinate synthase.
J. Biol. Chem. 280, 26645-26648 (2005)

Bhuiya, M. W., Sakuraba, H., Ohshima, T., Imagawa, T., Katunuma, N., & Tsuge, H.
The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
J. Mol. Biol. 345, 325-337 (2005)

-- 2004 --

Yamanaka, H., Morisada, N., Miyano, M., Tsuge, H., Shinoda, S., Takahashi, E., & Okamoto, K.
Amino-acid residues involved in the expression of the activity of Escherichia coli TolC.
Microbiol. Immunol. 48, 713-722 (2004)

Imagawa, T., Nakayama, H., Katunuma, N., Sakuraba, H., Ohshima, T., Itoh, T., Sako, Y., Nomura, N., & Tsuge, H.
Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I.
Acta Cryst. D 60, 2006-2008 (2004)

Bhuiya, M. W., Sakuraba, H., Yoneda, K., Ohshima, T., Imagawa, T., Katunuma, N., & Tsuge, H.
Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
Acta Cryst. D 60, 715-717 (2004)

-- 2003 --

Gao, H.-Z., Kobayashi, K., Tabata, A., Tsuge, H., Iijima, M., Yasuda, T., Kalkanoglu, H. S., Dursun, A., Tokatli, A., Coskun, T., Trefz, F. K., Skladal, D., Mandel, H., Seidel, J., Kodama, S., Shirane, S., Ichida, T., Makino, S., Yoshino, M., Kang, J.-H., Mizuguchi, M., Barshop, B. A., Fuchinoue, S., Seneca, S., Zeesman, S., Knerr, I., Rodes,M., Wasant, P., Yoshida, I., De Meirleir, L., Abdul Jalil, M., Begum, L., Horiuchi, M., Katunuma, N., Nakagawa, S., & Saheki, T.
Identification of 16 novel mutations in the argininosuccinate synthetase gene and genotype-phenotype correlation in 38 classical citrullinemia patients.
Hum. Mutat. 22, 24-34 (2003)

Sakurai, J., Nagahama, M., Hisatsune, J., Katunuma, N., & Tsuge, H.
Clostridium perfringens iota-toxin, ADP-ribosyltransferase: structure and mechanism of action.
Adv. Enzyme Regul. 43, 361-377 (2003)

Sakuraba, H., Tsuge, H., Shimoya, I., Kawakami, R., Goda, S., Kawarabayasi, Y., Katunuma, N., Ago, H., Miyano, M., & Ohshima, T.
The first crystal structure of archaeal aldolase. Unique tetrameric structure of 2-deoxy-d-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix.
J. Biol. Chem. 278, 10799-10806 (2003)

Tsuge, H., Nagahama, M., Nishimura, H., Hisatsune, J., Sakaguchi, Y., Itogawa, Y., Katunuma, N., & Sakurai, J.
Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin.
J. Mol. Biol. 325, 471-483 (2003)

-- 2002 --

Kihara, M., Kakegawa, H., Matano, Y., Murata, E., Tsuge, H., Kido, H., & Katunuma, N.
Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L.
Biol. Chem. 383, 1925-1929 (2002)

Tsuge, H., Sakuraba, H., Kobe, T., Kujime, A., Katunuma, N., & Ohshima, T.
Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-A resolution: a large conformational change in ADP-dependent glucokinase.
Protein Sci. 11, 2456-2463 (2002)

Bhuiya, M. W., Tsuge, H., Sakuraba, H., Yoneda, K., Katunuma, N., & Ohshima, T.
Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1.
Acta Cryst. D 58, 1338-1339 (2002)

Yoneda, K., Nishimura, T., Katunuma, N., Imamura, S., Nitta, K., & Tsuge, H.
Crystallization and preliminary X-ray crystallographic studies of monoacylglycerol lipase of the moderately thermophilic Bacillus sp. H-257.
Acta Cryst. D 58, 1232-1233 (2002)


学会発表

-- 2018 --

Yoshida T, Yamada T, Tsuge H
Membrane transport and ADP-ribosylation mechanism of binary toxin C. perfringens iota toxin
International Symposium on “Proteins; from the Cradle to the Grave”、比叡山延暦寺会館(京都),2018.8.26-29.

Yoshida T, Tsuge H
Substrate recognition and reaction mechanism of DNA-targeting guanine-specific ADP-ribosyltransferase International Symposium on “Proteins; from the Cradle to the Grave”、比叡山延暦寺会館(京都),2018.8.26-29.

Yamada T, Yoshida T, Tsuge H
Cryo-EM single particle analysis of C. perfringens binary toxin
International Symposium on “Proteins; from the Cradle to the Grave”、比叡山延暦寺会館(京都),2018.8.26-29.

津下英明
DNAを標的としたADPリボシル化酵素の基質認識機構
第453回ビタミンB 研究協議会、オークラホテル高松(香川),2018.8.31

津下英明
From Protein to DNA Modification: Substrate recognition mechanism in pierisin family DNA-targeting guanine-specific ADP-ribosyltransferase ScARP
第41回日本分子生物学会 ワークショップADP-ribosylation in intra- & extracellular communication and diseases、パシフィコ横浜,2018.12.3-6(シンポジウム口頭発表)

津下英明
Clostridium Binary Toxin:膜孔形成タンパク質トロンスロコンの作用機構について
京都薬科大学,2018.2.25

-- 2017 --

Toniti Waraphan, Yoshida Toru, Tsurumura Toshiharu, Irikura Daisuke, Monma Chie, Kamata Yoichi, Tsuge Hideaki
Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin(ポスター発表)
ETOX18 (European Workshop on Bacterial Protein Toxins)、Institut Pasteur(Paris)、2017.06.26-30

Yoshida Toru, Kobayashi Hidetomo, Yamanaka Hiroyasu, Tsuge Hideaki
Structural basis for action of the external chaperone for a propeptide-deficient serine protease from Aeromonas sobria(ポスター発表)
ETOX18 (European Workshop on Bacterial Protein Toxins)、Institut Pasteur(Paris)、2017.06.26-30

-- 2016 --

津下英明、戸田暁之、鶴村俊治、吉田徹
シンポジウム:モノ・ポリADPリボシル化によるシグナル伝達系の意義
C3 exoenzymeとRhoA複合体の結晶構造解析に基づく基質特異性(口頭発表)
第39回日本分子生物学会年会、パシフィコ横浜(横浜)、2016.11.30-12.02

村田晴香、吉田徹、津下英明
ウェルシュ菌産生イオタ毒素Ib成分のオリゴマーの調整
第89回日本生化学会大会、仙台国際センター(仙台)、2016.09.25-27

津下英明
細菌由来ADPリボシル化毒素の作用機構と基質特異性
大阪府立大学獣医学専攻オープンセミナー、大阪府立大学(大阪)、2016.07.22

Yoshida Toru, Tsuge Hideaki
ADP-ribosylation of RhoA by C3 exoenzyme.(口頭発表)
ICC05-AEM2016, Unazuki (Toyama, Japan), 2016.09.04-08

Toniti Waraphan, Yoshida Toru, Tsurumura Toshiharu, Irikura Daisuke, Monma Chie, Kamata Yoichi, Tsuge Hideaki
Characterization of actin ADP-ribosyltransferase from Clostridium perfringens iota-like enterotoxin.(口頭発表)
ICC05-AEM2016, Unazuki (Toyama, Japan), 2016.09.04-08

津下英明
WorkShop21:細菌病原性の分子機序研究の最前線
ADPリボシル化毒素C3がシグナル伝達阻害を引き起こすしくみ(口頭発表)
第89回日本細菌学会総会、大阪国際交流センター(大阪)、2016.03.23-25

津下英明、戸田暁之、鶴村俊治、吉田徹
ADPリボシル化毒素C3がシグナル伝達阻害を引き起こすしくみ(ポスター発表)
第89回日本細菌学会総会、大阪国際交流センター(大阪)、2016.03.23-25

-- 2015 --

吉田徹、小林秀丈、宮川拓也、田代充、岡本敬の介、山中浩泰、田之倉優、津下英明
Aeromonas sobria 由来プロペプチド欠損プロテアーゼの外部シャペロンによるフォールディング機構(口頭発表、ポスター発表)
第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会、神戸ポートアイランド(神戸)、2015.12.01-04

竹内理子、吉田徹、津下英明
DNAライブラリーから発現量の多い可用性領域を迅速に選択する手法の開発(ポスター発表)
第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会、神戸ポートアイランド(神戸)、2015.12.01-04

戸田暁之、鶴村俊治、吉田徹、津守耶良、津下英明
Structural basis of ADP-ribosyltransferase C3 exoenzyme with RhoA complex.(口頭発表)
第53回日本生物物理学会年会、金沢大学(金沢)、2015.09.13-15

Toniti Waraphan、吉田徹、 鶴村俊治、津下英明、芦田裕之、高橋香代、澤嘉弘
ラン藻アナベナ由来 12量体グルタミン合成酵素の結晶構造(ポスター発表)
第53回日本生物物理学会年会、金沢大学(金沢)、2015.09.13-15

津下英明
ADPリボシル化酵素C3とRhoA複合体の構造とその認識機構(口頭発表)
第441回ビタミンB研究協議会、ホテルコスモスクエア国際交流センター(大阪)、2015.09.04

Tsuge Hideaki
Structural basis of Bacterial ADP-ribosyltransferase and Human Protein Complex.(招待講演)
ETOX17 (European Workshop on Bacterial Protein Toxins), Braga (Portugal), 2015.06.20-24

-- 2014 --

津下英明
ADPリボシル化RhoAの立体構造に基づく阻害機構(口頭発表)
ビタミンB研究協議会、大阪、2014.11.22

津下英明
細菌感染症因子とホストタンパク質複合体の構造生物学 勝沼信彦先生とご一緒した12年間の健康科学研究所での思い出(招待講演)
第7回共同利用・共同研究「酵素学研究拠点」シンポジウム 勝沼信彦名誉教授追悼記念講演会、徳島大学(徳島)、2014.11.14

戸田暁之、江村晃太、吉田徹、津守耶良、鶴村俊治、津下英明
ADPリボシル化RhoAの構造とそのシグナル伝達への影響(ポスター発表)
第87回日本生化学会大会、国立京都国際会館(京都)、2014.10.15-18

鶴村俊治、津守耶良、秋こう、津下英明
ウェルシュ菌毒素IaによるactinのADPリボシル化機構(ポスター発表、口頭発表)
第61回日本生化学会 近畿支部年会、京都産業大学(京都)、2014.05.17

Yayoi Tsumori, Toshiharu Tsurumura, Hideaki Tsuge
Visualization of actin mono-ADP-ribosylation in iota toxin and actin complex structure.
2014 ASBMB annual meeting, SanDiego (USA), 2014.04.26-30

-- 2013 --

Toshiharu Tsurumura, Hideaki Tsuge
Substrate Selectivity of Monoacylglycerol Lipase based on the Crystal Structure.
The 7th International Conference on Structural Genomics, Sapporo (Japan), 2013.07.31

鶴村俊治、津守耶良、秋浩、津下英明
Ia-actin 複合体結晶場におけるADPリボシル化の捕捉(ポスター発表)
第13回日本蛋白質科学会年会、とりぎん文化会館(鳥取)、2013.06.12-14

津下英明
病原菌をさらに理解するための構造生物学(招待講演)
第86回細菌学会総会、幕張メッセ国際会議場(千葉)、2013.03.18-20

-- 2012 --

鶴村俊治津下英明
モノアシルグリセロールリパーゼの二量体形成はその機能に重要か?(ポスター発表)
第85回日本生化学会大会、福岡国際会議場・マリンメッセ福岡(福岡)、2012.12.14-16

秋こう、鶴村俊治、畠山大、葛原隆、津下英明
A型インフルエンザウィルスRNAポリメラーゼPB2の構造と機能(ポスター発表)
第85回日本生化学会大会、福岡国際会議場・マリンメッセ福岡(福岡)、2012.12.14-16

秋こう、鶴村俊治、津下英明、吉田賢右
創薬標的であるインフルエンザウィルスRNAポリメラーゼの構造研究
イノベーションフェア関西、大阪国際会議場(大阪)、2012.12.06

津下英明
アルギニンADPリボシル化初めての可視化(口頭発表)
ビタミンB研究協議会、京都国際交流会館(京都)、2012.11.17

Hideaki Tsuge, Toshiharu Tsurumura, Masataka Oda, Masahiro Nagahama
Actin Recognition and ADP-ribosylation of C. perfringens iota-toxin.
The 11th Awaji International Forum on Infection and Immunity, Awaji (Japan), 2012.09.13

鶴村俊治、津守耶良、秋こう、津下英明
アクチンADPリボシル化反応に伴う酵素の構造変化(ポスター発表)
第12回日本蛋白質科学会年会、名古屋国際会議場(名古屋)、2012.06.20-22

津下英明
ADPリボシル化反応に伴う酵素の構造変化(口頭発表)
ビタミンB研究協議会、京都国際交流会館(京都)、2012.02.04

-- 2011 --

津下英明
ADPリボシル化毒素構造研究の最前線
シンポジウム「疾患治療に用いる天然有機化合物の生合成遺伝子の包括的理解」、徳島文理大学(徳島)、2011.12.22

今川貴仁、津下英明
高度好熱菌HB8由来のフラビン還元酵素の構造機能解析
第422回研究ビタミンB協議会、京都、2011.11.27

津下英明
アクチンADPリボシル化の構造基盤
シンポジウム「ADPリボシル化によるシグナル伝達制御」
第84会日本生化学会大会、京都国際会館(京都)、2011.09.21-24

津下英明
感染症因子とヒトタンパク質の相互作用を見る
X線の会、阪急グランドビル(大阪)、2011.09.10

Tsurumura Toshiharu, Tsuge Hideaki
Crystal structure of Ia-Actin complex with novel ligand.
22nd IUCR Congress (International Union of Crystallography), Madrid (Spain), 2011.08.25-26

Tsurumura Toshiharu, Tsuge Hideaki
Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.
22nd IUCR Congress (International Union of Crystallography), Madrid (Spain), 2011.08.25-26

鶴村俊治、津下英明
ADPリボシル化毒素によるアクチン認識の特異性解析
第11回日本蛋白質科学会年会、ホテル阪急エキスポパーク(大阪)、2011.06.07-09


著書

共著
構造生物学 -ポストゲノム時代のタンパク質研究-
共立出版 (2007) (倉光成紀、杉山政則 編)

小田真隆、津下英明、櫻井純
溶血性貧血・アトピーの治療に活躍するタンパク質:スフィンゴミエリナーゼ
P91-99

櫻庭春彦、津下英明、大島敏久
超好熱菌由来酵素を創薬に利用:2-デオキシ-D-リボース-5-リン酸アルドラーゼ
P169-175

櫻庭春彦、津下英明、大島敏久
バイオセンサー素子としてのアミノ酸脱水素酵素の構造と機能
P184-191

共著
最先端創薬4 -戦略的アプローチと先端的医薬品-
蛋白質核酸酵素 (2000)

勝沼信彦、浅尾哲次、津下英明
特異的カテプシン阻害剤の開発とその医学応用
p1057-1064