Our Research

Exploration of therapeutic target molecules and identification of the mechanisms for neural disease and cancer. Solid tumor growth in animals and in man is accompanied by neovascularization called angiogenesis. New capillary growth is elicited by a diffusible factor such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) generated by malignant tumor cells. There is evidence that overexpression of VEGF and FGF correlate poor prognosis. We are investigating the molecular mechanisms whereby VEGF and FGF mediate tumor progression. Our contributions in these research fields are expected to lead to the development of regenerative therapies for neuronal disorder patients, which are currently the center of attention as well as novel cancer treatments.

Research project

  1. VEGF-A induces VEGFR-independent signaling, Neuropilin dependent Tumorigenesis.


  2. Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Cancer Malignant Progression.

  3. Anosmin-1 inhibits Growth Cone Collapse induced by RGMa/Neogenin signaling.