Our Research
Exploration of therapeutic target molecules and identification
of the mechanisms for neural disease and cancer.
Solid
tumor growth in animals and in man is accompanied by neovascularization
called angiogenesis. New capillary growth is elicited by a diffusible
factor such as vascular endothelial growth factor (VEGF) and fibroblast
growth factor (FGF) generated by malignant tumor cells. There is
evidence that overexpression of VEGF and FGF correlate poor prognosis.
We are investigating the molecular mechanisms whereby VEGF and FGF
mediate tumor progression. Our contributions in these research fields
are expected to lead to the development of regenerative therapies for
neuronal disorder patients, which are currently the center of attention
as well as novel cancer treatments.
Research project
- VEGF-A induces VEGFR-independent signaling, Neuropilin dependent Tumorigenesis.
- Enhanced
Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human
Esophageal Cancer Malignant Progression.
- Anosmin-1 inhibits Growth Cone Collapse induced by RGMa/Neogenin signaling.
Contact:
Misuzu (Kurokawa) Seo, PhD Professor
〒603-8555
Kamigamo, Motoyama, Kita-ku,
Kyoto city
Tel: 81-75-705-1488
E-mail: mseo@cc.kyoto-su.ac.jp