01
G Protein-Coupled Receptors (GPCRs)
Dopamine, serotonin, and histamine receptors are key G protein-coupled receptors (GPCRs) involved in emotional regulation, cognition, and reward circuitry...
Key Research Directions:
- Structural basis of GPCR activation and signaling
- GPCR-G protein and GPCR-arrestin complex structures
- Allosteric modulation mechanisms
- Structure-based ligand discovery
02
Membrane Transporters
At the synaptic terminal, the release, reuptake, and storage of monoamines must be precisely orchestrated...
Key Research Directions:
- Conformational dynamics of monoamine transporters
- Proton- and ion-coupled transport mechanisms
- ntermediate states and substrate translocation pathways
- Structural integration of GPCR signaling and transporter regulation at synapses
03
Antibody Platform
Antibodies represent one of the fastest-growing classes of therapeutic molecules. Our research focuses on elucidating the structural basis of antibody-antigen recognition and antibody engineering for improved therapeutic efficacy. We employ structural biology approaches to design next-generation antibody therapeutics with enhanced specificity, affinity, and reduced immunogenicity.
Key Research Directions:
- Conformation-specific antibody stabilization of membrane proteins
- Cryo-EM analysis of antibody–receptor complexes
- Structural integration of functional modulation and imaging approaches
- Translational applications toward diagnostics and precision therapeutics
