OUR WORK

Publications

Our research contributions to the field

2026

Decarboxylation via a Higher Electronic Excited State Drives LSSmOrange Photoconversion.
HS Seol, F Luo, ED Zitter, N Nuemket, E Fron, NR Mcfarlane, LDe Vrieze, J Civic, M Postelmans, SV Bel, S Owada, K Tono, T Tanaka, T Arima, H Noguchi, TYH Bui, R Tanaka, K Hasegawa, K Hirata, D Im, T Araya, T Kimura, LV Meervelt, M Weik, JN Harvey, JP Colletier, S Iwata*, E Nango*, H Mizuno*
ACS Phys. Chem. Au. 2026, XX(X):XXX-XXX.
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Structural basis for the subtype-selectivity of KCa2.2 channel activators.
Y Nam, A Ramanishka, Y Xu, RMH Yasuda, JA Nasburg, D Im, M Cui, K.G Chandy, H Wulff, M Zhang*
Nature Commun. 2026, 17(1):531.
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2025

Structural insights into the G protein subtype selectivity revealed by human Sphingosine-1-Phospate Receptor 3-Gq complexes.
M Yamauchi, D Im*, S Maeda, T Ikuta, M Toyomoto, H Asada, Y Sugita, J Kishikawa, T Noda, T Kato, A Inoue, S Iwata*, and M Hagiwara*
Proc Natl Acad Sci USA. 2025, 122(47):e2507421122.
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Discovery and development of an oral analgesic targeting the α2B adrenoceptor.
M Toyomoto, T Kurihara, T Nakagawa, A Inoue, R Kimura, I Kii, T Sawada, T Ogihara, K Nagayasu, T Kishi, H Onogi, D Im, H Asada, S Iwata, J Taguchi, Y Sumida, S Yoshida, J Aoki, T Hosoya, M Hagiwara.
Proc Natl Acad Sci USA. 2025, 122(32):e2500006122.
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Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel.
Y Nam, D Im, A.S.C. Garcia, ML. Tringides, H.M. Nguyen, Y Liu, R Orfali, A Ramanishka, G Pintilie, C Su, M. Cui, D.E. Logothetis, E.W. Yu, H. Wulff, K.G. Chandy, M. Zhang*.
Nature Commun. 2025, 16(1):3690.
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The structure and function of the ghrelin receptor coding for drug actions.
Y Shiimura*#, D Im#, R Tany, H Asada, R Kise, E Kurumiya, HW Masuho, S Yasuda, K Matsui, J Kishikawa, T Kato, T Murata, M Kojima, S Iwata*, I Masuho*.
Nat Struct Mol Biol. 2025, 32(3):531-542.
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2024

Neurotransmitter Recognition by Human Vesicular Monoamine Transporter 2.
D Im#*, M Jormakka#, N Juge#, J Kishikawa, T Kato, Y Sugita, T Noda, T Uemura, Y Shiimura, T Miyaji, H Asada, S Iwata*.
Nature Commun. 2024, 15(1):7661.
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Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor.
T Araya, Y Matsuba, H Suzuki, T Doura, N Nuemket, E Nango, M Yamamoto, D Im, H Asada*, S Kiyonaka*, S Iwata*.
Biochem Biophys Res Commun. 2024, 695:149393.
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2023

Structural Insights into the Agonists Binding and Receptor Selectivity of Human Histamine H4 Receptor.
D Im#, J Kishikawa#, Y Shiimura, H Hisano, A Ito, YF Fujiharu, Y Sugita, T Noda, T Kato*, H Asada*, S Iwata*.
Nature Commun. 2023, 14(1):6538.
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Mapping Protein Dynamics at High Spatial Resolution with Temperature-Jump X-ray Crystallography.
AM Wolff, E Nango*, ID Young, AS Brewster, M Kubo, T Nomura, M Sugahara, S Owada, BA Barad, K Ito, A Bhowmick, S Carbajo, T Hino, JM Holton, D Im, LJ O’Riordan, T Tanaka, R Tanaka, RG Sierra, F Yumoto, K Tono, S Iwata, NK Sauter, JS Fraser, MC Thompson*.
Nature Chem. 2023, 15(11):1549-1558.
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2022

Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.
H Asada*, D Im, Y Hotta, S Yasuda, T Murata, R Suno, S Iwata*.
Structure. 2022, 30(12):1582-1589.
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2021

S1PR3-Gbiased agonist ALESIA targets cancer metabolism and promotes glucose starvation.
M Toyomoto, A Inoue, K Iida, M Denawa, I Kii, FMN Kadji, T Kishi, D Im, T Shimamura, H Onogi, S Yoshida, S Iwata, J Aoki, T Hosoya and M Hagiwara*.
Cell Chem Biol. 2021, 28(8):1132-1144.
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2020

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.
D Im, A Inoue, T Fujiwara, T Nakane, Y Yamanaka, T Uemura, C Mori, Y Shiimura, KT Kimura, H Asada, N Nomura, T Tanaka, A Yamashita, E Nango, K Tono, FMN Kadji, J Aoki, S Iwata*, T Shimamura*.
Nature Commun. 2020, 11(1):644.
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Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
AM Wolff, ID Young, RG Sierra, AS Brewster, MW Martynowycz, E Nango, M Sugahara, T Nakane, K Ito, A Aquila, A Bhowmick, JT Biel, S Carbajo, AE Cohen, S Cortez, A Gonzalez, T Hino, D Im, JD Koralek, M Kubo, TS Lazarou, T Nomura, S Owada, AJ Samelson, T Tanaka, R Tanaka, EM Thompson, H van den Bedem, RA Woldeyes, F Yumoto, W Zhao, K Tono, S Boutet, S Iwata, T Gonen, NK Sauter, JS Fraser, MC Thompson*.
IUCrJ. 2020, 7(2):306-323.
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The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
H Asada*, A Inoue, FMN Kadji, K Hirata, Y Shiimura, D Im, T. Shimamura, N Nomura, H Iwanari, T Hamakubo, O Kusano-Arai, H Hisano, T Uemura, C Suno, J Aoki, S Iwata*.
Structure. 2020, 28(4):418-425.
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2019

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.
KT Kimura, H Asada, A Inoue, FMN Kadji, D Im, C Mori, T Arakawa, K Hirata, Y Nomura, N Nomura, J Aoki, S Iwata*, T Shimamura*.
Nat Struct Mol Biol. 2019, 26(2):121-128.
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2018

Ligand complex structures of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 and its conformational change.
D Im, D Matsui, T Arakawa, K Isobe, Y Asano, S Fushinobu*.
FEBS Open Bio. 2018, 8(3):314-324.
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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
R Suno*, KT Kimura, T Nakane, K Yamashita, J Wang, T Fujiwara, Y Yamanaka, D Im, S Horita, H Tsujimoto, MS Tawaramoto, T Hirokawa, E Nango, K Tono, T Kameshima, T Hatsui, Y Joti, M Yabashi, K Shimamoto, M Yamamoto, DM Rosenbaum, S Iwata*, T Shimamura*, T Kobayashi*.
Structure. 2018, 26(1):7-19.
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2016

A three-dimensional movie of structural changes in bacteriorhodopsin.
E Nango, A Royant, M Kubo, T Nakane, C Wickstrand, T Kimura, T Tanaka, K Tono, C Song, R Tanaka, T Arima, A Yamashita, J Kobayashi, T Hosaka, E Mizohata, P Nogly, M Sugahara, D Nam, T Nomura, T Shimamura, D Im, T Fujiwara, Y Yamanaka, B Jeon, T Nishizawa, K Oda, M Fukuda, R Andersson, P Båth, R Dods, J Davidsson, S Matsuoka, S Kawatake, M Murata, O Nureki, S Owada, T Kameshima, T Hatsui, Y Joti, G Schertler, M Yabashi, AN Bondar, J Standfuss, R Neutze*, S Iwata*.
Science. 2016, 354(6319):1552-1557.
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2014

Mutational and crystallographic analysis of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813.
D Matsui#, D Im#, A Sugawara, Y Fukuta, S Fushinobu, K Isobe, Y Asano*.
FEBS Open Bio. 2014, 4(1):220-228.
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2012

Crystal structures of glycoside hydrolase family 51 α-L-arabinofuranosidase from Thermotoga maritima.
D Im, K Kimura, F Hayasaka, T Tanaka, M Noguchi, A Kobayashi, S Shoda, K Miyazaki, T Wakagi, S Fushinobu*.
Biosci Biotechnol Biochem. 2012; 76(2):423-238.
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