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-- 2020 --

Yamada T, Yoshida T, Kawamoto A, Mitsuoka K, Iwasaki K, & Tsuge H.
Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex.
Nat Struct & Mol Biol. 27(3):288-296. (2020)

-- 2018 --

Yoshida T. & Tsuge, H.
Substrate N2 atom recognition mechanism in pierisin family DNA-targeting, guanine-specific ADP-ribosyltransferase ScARP.
J. Biol. Chem. 293, 13768-13774 (2018)

Suzuki Y., Tsuge H., Hondoh H., Kato Y., Uehara Y., Maita N., Hosokawa K., & Ueta S.
Precipitant-Free Lysozyme Crystals Grown by Centrifugal Concentration Reveal Structural Changes.
Crystal Growth and Design 18(8), 4226-4229

-- 2017 --

Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, Okamoto K, Yoshida T, Tsuge H, & Yamanaka H.
Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity.
PLoS ONE 12, e0186392 (2017)

-- 2017 --

Toniti, W., Yoshida, T., Tsurumura, T., Irikura, D., Monma, C., Kamata, Y., & Tsuge, H.
Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin.
PLoS ONE 12, e0171278 (2017)

Tsuge, H., Tsurumura, T., Toda, A., Murata, H., Toniti, W., & Yoshida, T.
Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology.
Curr. Top. Microbiol. Immunol. 399, 69-86 (2017)

-- 2016 --

Toda, A., Tsurumura, T., Yoshida, T., Tsumori, Y., & Tsuge, H.
Structural Basis of Rho GTPase Recognition by C3 Exoenzyme.
Photon Factory Highlights 2015 58-59 (2016)

Yoshida, T., Ogola, H. J. O., Amano, Y., Hisabori, T., Ashida, H., Sawa, Y., Tsuge, H., & Sugano, Y.
Anabaena sp.DyP-type peroxidase is a tetramer consisting of two asymmetric dimers.
Proteins 84, 31-42 (2016)

-- 2015 --

Tsuge, H., Yoshida, T., & Tsurumura, T.
Conformational plasticity is crucial for C3-RhoA complex formation by ARTT-loop.
Pathog. Dis. 73, ftv094 (2015)

Toda, A., Tsurumura, T., Yoshida, T., Tsumori, Y., & Tsuge, H.
Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure.
J. Biol. Chem. 290, 19423-19432 (2015)

Kobayashi, H., Yoshida, T., Miyakawa, T., Tashiro, M., Okamoto, K., Yamanaka, H., Tanokura, M., & Tsuge, H.
Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria.
J. Biol. Chem. 290, 11130-11143 (2015)

Tsuge, H. & Tsurumura, T.
Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein.
Curr. Top. Microbiol. Immunol. 384, 69-87 (2015).

-- 2014 --

Tsurumura, T. & Tsuge, H.
Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure.
J. Struct. Funct. Genomics 15, 83-89 (2014).

Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y. & Tsuge, H.
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.
Acta Cryst. F 70, 72-75 (2014).

-- 2013 --

Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y., Hatakeyama, D., Kuzuhara, T., & Tsuge, H.
Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus.
PLoS ONE 8, e82020 (2013).

Tsurumura, T., Tsumori, Y., Qiu, H., Oda, M., Sakurai, J., Nagahama, M., & Tsuge, H.
Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex.
Proc. Natl. Acad. Sci. U.S.A. 110, 4267-4272 (2013).

-- 2012 --

Kuzuhara, T. & Tsuge, H.
The tertiary structures of the domains of influenza RNA polymerase.
Seikagaku 84, 780-785 (2012).

Yoshida, T., Tsuge, H., Hisabori, T. & Sugano, Y.
Crystal structures of dye-decolorizing peroxidase with ascorbic acid and 2,6-dimethoxyphenol.
FEBS Lett. 586, 4351-4356 (2012).

Oda, M., Hashimoto, M., Takahashi, M., Ohmae, Y., Seike, S., Kato, R., Fujita, A., Tsuge, H., Nagahama, M., Ochi, S., Sasahara, T., Hayashi, S., Hirai, Y., & Sakurai, J.
Role of sphingomyelinase in infectious diseases caused by Bacillus cereus.
PLoS ONE 7, e38054 (2012).

Oda, M., Takahashi, M., Tsuge, H., Nagahama, M. & Sakurai, J.
Role of side-edge site of sphingomyelinase from Bacillus cereus.
Biochem. Biophys. Res. Commun. 422, 128-132 (2012).

-- 2011 --

Imagawa, T., Tsurumura, T., Sugimoto, Y., Aki, K., Ishidoh, K., Kuramitsu, S., & Tsuge, H.
Structural basis of free reduced flavin generation by flavin reductase from Thermus thermophilus HB8.
J. Biol. Chem. 286, 44078-44085 (2011).

Ohtomo, H., Konuma, T., Utsunoiya, H., Tsuge, H. & Ikeguchi, M.
Structure and stability of Gyuba, a β-lactoglobulin chimera.
Protein Sci. 20, 1867-1875 (2011).

Yoshida, T., Tsuge, H., Konno, H., Hisabori, T. & Sugano, Y.
The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue.
FEBS J. 278, 2387-2394 (2011).

-- 2010 --

Watanabe, T., Tsuge, H., Imagawa, T., Kise, D., Hirano, K., Beppu, M., Takahashi, A., Yamaguchi, K., Fujiki, H., & Suganuma, M.
Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori.
J. Cancer Res. Clin. Oncol. 136, 911-921 (2010).

-- 2009 --

Kobayashi, H., Tateishi, A., Tsuge, H., Takahashi, E., Okamoto, K., & Yamanaka, H.
The carboxy-terminal tail of Aeromonas sobria Serine Protease is associated with the chaperone.
Microbiol. Immunol. 53, 647-657 (2009).

Sakurai, J., Nagahama, M., Oda, M., Tsuge, H. & Kobayashi, K.
Clostridium perfringens iota-toxin: structure and function.
Toxins (Basel) 1, 208-228 (2009).

Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K., & Tsuge, H.
Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.
J. Biol. Chem. 284, 27655-27663 (2009).

Tsuge, H., Tsurumura, T., Utsunomiya, H., Kise, D., Kuzuhara, T., Watanabe, T., Fujiki, H., & Suganuma, M.
Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.
Biochem. Biophys. Res. Commun. 388, 193-198 (2009).

Kawakami, R., Sakuraba, H., Goda, S., Tsuge, H. & Ohshima, T.
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.
Biochim. Biophys. Acta 1794, 1496-1504 (2009).

Kuzuhara, T., Kise, D., Yoshida, H., Horita, T., Murazaki, Y., Utsunomiya, H., & Tsuge, H.
Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2.
Acta Cryst. F 65, 144-146 (2009)

Kuzuhara, T., Kise, D., Yoshida, H., Horita, T., Murazaki, Y., Nishimura, A., Echigo, N., Utsunomiya, H., & Tsuge, H.
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue.
J. Biol. Chem. 284, 6855-6860 (2009).

Tsukamoto, S., Yamashita, T., Yamada, Y., Fujiwara, K., Maki, K., Kuwajima, K., Matsumura, Y., Kihara, H., Tsuge, H., & Ikeguchi, M.
Non-native alpha-helix formation is not necessary for folding of lipocalin: comparison of burst-phase folding between tear lipocalin and beta-lactoglobulin.
Proteins 76, 226-236 (2009).

Nakaishi, Y., Bando, M., Shimizu, H., Watanabe, K., Goto, F., Tsuge, H., Kondo, K., & Komatsu, M.
Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes.
FEBS Lett. 583, 163-167 (2009).

-- 2008 --

Sakuraba, H., Yoneda, K., Takeuchi, K., Tsuge, H., Katunuma, N., & Ohshima, T.
Structure of an archaeal alanine:glyoxylate aminotransferase.
Acta Cryst. D 64, 696-699 (2008).

Tsuge, H., Nagahama, M., Oda, M., Iwamoto, S., Utsunomiya, H., Marquez, V. E., Katunuma, N., Nishizawa, M., & Sakurai, J.
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin.
Proc. Natl. Acad. Sci. U.S.A. 105, 7399-7404 (2008).

Sakuraba, H., Yoneda, K., Asai, I., Tsuge, H., Katunuma, N., & Ohshima, T.
Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii.
Biochim. Biophys. Acta. 1784, 563-571 (2008)

Imagawa, T., Iino, H., Kanagawa, M., Ebihara, A., Kuramitsu, S., & Tsuge, H.
Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase.
Biochem. Biophys. Res. Commun. 367, 535-541 (2008)

-- 2007 --

Kawazoe, T., Park, H. K., Iwana, S., Tsuge, H., & Fukui, K.
Human D-amino acid oxidase: an update and review.
Chem. Rec. 7, 305-315 (2007)

Sakuraba, H., Yoneda, K., Yoshihara, K., Satoh, K., Kawakami, R., Uto, Y., Tsuge, H., Takahashi, K., Hori, H., & Ohshima, T.
Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase.
Appl. Environ. Microbiol. 73, 7427-7434 (2007)

Yoneda, K., Sakuraba, H., Tsuge, H., Katunuma, N., & Ohshima, T.
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.
FEBS J. 274, 4315-4325 (2007)

Kawazoe, T., Tsuge, H., Imagawa, T., Aki, K., Kuramitsu, S., & Fukui, K.
Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis.
Biochem. Biophys. Res. Commun. 355, 385-391 (2007)

Nakayama, H., Shimamura, T., Imagawa, T., Shirai, N., Itoh, T., Sako, Y., Miyano, M., Sakuraba, H., Ohshima, T., Nomura, N., & Tsuge, H.
Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability.
J. Mol. Biol. 365, 362-378 (2007)

-- 2006 --

Kawazoe, T., Tsuge, H., Pilone, M. S., & Fukui, K.
Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring.
Protein Sci. 15, 2708-2717 (2006)

Ago, H., Oda, M., Takahashi, M., Tsuge, H., Ochi, S., Katunuma, N., Miyano, M., & Sakurai, J.
Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus.
J. Biol. Chem. 281, 16157-16167 (2006)

Tsuge, H., Aki, K., Katanuma, N., Kawakami, R., Sakuraba, H., & Ohshima, T.
Novel diflavin-containing dehydrogenase family: FAD, FMN and ATP-containing L-proline dehydrogenase.
Seikagaku 78, 41-45 (2006)

-- 2005 --

Yoneda, K., Sakuraba, H., Tsuge, H., Katunuma, N., Kuramitsu, S., Kawabata, T., & Ohshima, T.
The first crystal structure of an archaeal helical repeat protein.
Acta Cryst. F 61, 636-639 (2005)

Kuzuhara, T., Suganuma, M., Tsuge, H., & Fujiki, H.
Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins.
Biol. Pharm. Bull. 28, 2133-2137 (2005)

Kawakami, R., Sakuraba, H., Tsuge, H., Goda, S., Katunuma, N., & Ohshima, T.
A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3.
FEBS J. 272, 4044-4054 (2005)

Tsuge, H., Kawakami, R., Sakuraba, H., Ago, H., Miyano, M., Aki, K., Katunuma, N., & Ohshima, T.
Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii.
J. Biol. Chem. 280, 31045-31049 (2005)

Sakuraba, H., Tsuge, H., Yoneda, K., Katunuma, N., & Ohshima, T.
Crystal structure of the NAD biosynthetic enzyme quinolinate synthase.
J. Biol. Chem. 280, 26645-26648 (2005)

Bhuiya, M. W., Sakuraba, H., Ohshima, T., Imagawa, T., Katunuma, N., & Tsuge, H.
The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
J. Mol. Biol. 345, 325-337 (2005)

-- 2004 --

Yamanaka, H., Morisada, N., Miyano, M., Tsuge, H., Shinoda, S., Takahashi, E., & Okamoto, K.
Amino-acid residues involved in the expression of the activity of Escherichia coli TolC.
Microbiol. Immunol. 48, 713-722 (2004)

Imagawa, T., Nakayama, H., Katunuma, N., Sakuraba, H., Ohshima, T., Itoh, T., Sako, Y., Nomura, N., & Tsuge, H.
Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I.
Acta Cryst. D 60, 2006-2008 (2004)

Bhuiya, M. W., Sakuraba, H., Yoneda, K., Ohshima, T., Imagawa, T., Katunuma, N., & Tsuge, H.
Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.
Acta Cryst. D 60, 715-717 (2004)

-- 2003 --

Gao, H.-Z., Kobayashi, K., Tabata, A., Tsuge, H., Iijima, M., Yasuda, T., Kalkanoglu, H. S., Dursun, A., Tokatli, A., Coskun, T., Trefz, F. K., Skladal, D., Mandel, H., Seidel, J., Kodama, S., Shirane, S., Ichida, T., Makino, S., Yoshino, M., Kang, J.-H., Mizuguchi, M., Barshop, B. A., Fuchinoue, S., Seneca, S., Zeesman, S., Knerr, I., Rodes,M., Wasant, P., Yoshida, I., De Meirleir, L., Abdul Jalil, M., Begum, L., Horiuchi, M., Katunuma, N., Nakagawa, S., & Saheki, T.
Identification of 16 novel mutations in the argininosuccinate synthetase gene and genotype-phenotype correlation in 38 classical citrullinemia patients.
Hum. Mutat. 22, 24-34 (2003)

Sakurai, J., Nagahama, M., Hisatsune, J., Katunuma, N., & Tsuge, H.
Clostridium perfringens iota-toxin, ADP-ribosyltransferase: structure and mechanism of action.
Adv. Enzyme Regul. 43, 361-377 (2003)

Sakuraba, H., Tsuge, H., Shimoya, I., Kawakami, R., Goda, S., Kawarabayasi, Y., Katunuma, N., Ago, H., Miyano, M., & Ohshima, T.
The first crystal structure of archaeal aldolase. Unique tetrameric structure of 2-deoxy-d-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix.
J. Biol. Chem. 278, 10799-10806 (2003)

Tsuge, H., Nagahama, M., Nishimura, H., Hisatsune, J., Sakaguchi, Y., Itogawa, Y., Katunuma, N., & Sakurai, J.
Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin.
J. Mol. Biol. 325, 471-483 (2003)

-- 2002 --

Kihara, M., Kakegawa, H., Matano, Y., Murata, E., Tsuge, H., Kido, H., & Katunuma, N.
Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L.
Biol. Chem. 383, 1925-1929 (2002)

Tsuge, H., Sakuraba, H., Kobe, T., Kujime, A., Katunuma, N., & Ohshima, T.
Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-A resolution: a large conformational change in ADP-dependent glucokinase.
Protein Sci. 11, 2456-2463 (2002)

Bhuiya, M. W., Tsuge, H., Sakuraba, H., Yoneda, K., Katunuma, N., & Ohshima, T.
Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1.
Acta Cryst. D 58, 1338-1339 (2002)

Yoneda, K., Nishimura, T., Katunuma, N., Imamura, S., Nitta, K., & Tsuge, H.
Crystallization and preliminary X-ray crystallographic studies of monoacylglycerol lipase of the moderately thermophilic Bacillus sp. H-257.
Acta Cryst. D 58, 1232-1233 (2002)