原著論文 / Original articles
2000〜2009
・Y. Ishida & Kazuhiro Nagata
Autophagy eliminates a specific species of misfolded procollagen
and plays a protective role in cell survival against ER stress.
Autophagy5(8): 1217-1219(2009)
・M. Ikeda, M. Naitoh, H. Kubota, T. Ishiko, K. Yoshikawa, S. Yamawaki,
M. Kurokawa, A. Utani, T. Nakamura, K. Nagata & S. Suzuki
Elastic fiber assembly is disrupted by excessive accumulation of
chondroitin sulfate in the human dermal fibrotic disease, keloid.
Biochem Biophys Res Commun.390:1221-1228(2009)
・Y.Ishikawa, J.Wirz, J.A.Vranka, K.Nagata & H.P.B?chinger
Biochemical Characterization of the Prolyl 3-Hydroxylase
1oCartilage-associated ProteinoCyclophilin B Complex
J. Biol. Chem.284(26): 17641-17647 (2009)
・N. HOSOKAWA, Y. KAMIYA, D. KAMIYA, K. KATO & K. NAGATA
Human OS-9, a lectin required for glycoprotein endoplasmic
reticulum-associated degradation, recognizes mannose-trimmed
N-Glycans.
J Biol Chem. 284 (25):17061-17068 (2009)
・Y. ISHIDA, A. YAMAMOTO, A. KITAMURA, SR LAMANDE, T. YOSHIMORI,
FB JOHN, H.KUBOTA & K. NAGATA
Autophagic elimination of misfolded procollagen aggregates in the
endoplasmic reticulum as a means of cell protection.
Mol. Biol. Cell. 20 (11):2744-2754(2009)
・N.HOSOKAWA & K.NAGATA
M-type lectins as novel components of secretory pathways.
In“ANIMAL LECTINS A Functional View”(Eds Gerardo R.Vasta, Hafiz Ahmed)
CRC Press pp.165-169(2009)
・T. KAKUGAWA, S. YOKOTA, H. MUKAE, H. KUBOTA, N. SAKAMOTO,
S. MIZUNOE, Y.
MATSUOKA, J. KADOTA, N. HUJII, K.NAGATA & S. KOHNO
High serum concentrations of autoantibodies to HSP47 in
nonspecific interstitial pneumonia compared with idiopathic
pulmonary fibrosis.
BMC Pulm Med. 8 (23):1-6(2008)
・Y. ISHIKAWA, J. VRANKA, J. WIRZ, K. NAGATA & HP BACHINGER
The rough endoplasmic reticulum-resident FK506-binding protein
FKBP65 is a molecular chaperone that interacts with collagens.
J Biol Chem. 283 (46):31584-31590 (2008)
・R.USHIODA, J.HOSEKI, K.ARAKI, G.JANSEN , D.Y.THOMAS, & K.NAGATA
ERdj5 is required as a disulfide reductase for degradation of
misfolded proteins in the ER.
Science <321 (5888):569-72(2008)
・N.HOSOKAWA, I.WADA, K.NAGASAWA, T.MORIYAMA, K.OKAWA, & K.NAGATA
Human XTP3-B Forms an Endoplasmic Reticulum Quality Control
Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP.
J Biol Chem. 283 (30):20914-24(2008)
・J.NAKAMURA, M.FUJIMOTO, K.YASUDA, K.TAKEDA, S.AKIRA,
T.HATAYAMA,Y.TAKAGI, K.NOZAKI, N.HOSOKAWA, & K.NAGATA
Targeted Disruption of Hsp110/105 Gene Protects against
Ischemic Stres.
Ischemic Stress Stroke39:2853-2859(2008)
・S.NAKAYAMA, H.MUKAE, N.SAKAMOTO, T.KAKUGAWA, S.YOSHIOKA, H.SODA,
H.OKU, Y.URATA, T.KONDO, H.KUBOTA, K.NAGATA & S.KOHNO
Pirfenidone inhibits the expression of HSP47 in TGF-beta1
-stimulated human lung fibroblasts.
Life Sci. 82 :210-217(2008)
・D.MORITO, K.HIRAO, F.TOKUNAGA, N.HOSOKAWA, D.M. CYR, K.TANAKA,
K.IWAI & K.NAGATA
Gp78 cooperates with RMA1 in ER-associated degradation of
CFTRΔF508.
Mol. Biol. Cell. 19 :1328-1336(2008)
・S.HIRAYAMA, Y.YAMAZAKI, A.KITAMURA, Y.ODA, D.MORITO, K.OKAWA,
H.KIMURA, D.M.CYR, H.KUBOTA & K.NAGATA
MKKS is a centrosome-shuttling protein degraded by disease
-causing mutations via CHIP-mediated ubiquitination.
Mol. Biol. Cell. 19 :899-911(2008)
・N.HOSOKAWA, Z.YOU, L.O.TREMBLAY, K.NAGATA, A.HERSCOVICS
Stimulation of ERAD of misfolded null Hong Kong alfa-antitrypsin
by Golgi alfa1,2-mannosidases.
Biochem Biophys Res Commun. 362 :626-632(2007)
・S.YOSHIOKA, H.MUKAE, H.ISHII, T.KAKUGAWA, H.ISHIMOTO, N.SAKAMOTO,
T.HUJII, Y.URATA, T.KONDO, H.KUBOTA, K.NAGATA, S.KOHNO
Alpha-defensin enhaces expression of HSP47 and collagen-1 in
human lung fibrolasts.
Life Sciences 80 :1839-1845(2007)
・N.MIZOBUCHI, J.HOSEKI, H.KUBOTA, S.TOYOKUNI, J.NOZAKI, M.NAITOH,
A.KOIZUMI & K.NAGATA
ARMET is a soluble ER protein induced the unfolded protein
response via ERSE-II element.
Cell Srtuct. and Funct. 32 :41-50(2007)
・K.NAGASAWA, T.HIGASHI, N.HOSOKWA, R.J. KAUFMAN & K.NAGATA
Simultaneous induction of the four subunits of TRAP complex by
ER stress accelerates ER degradation.
EMBO Rep.8 (5):483-490(2007)
・A.OGURO , T.SAKURAI, Y.FUJITA, S.LEE, H.KUBOTA, K.NAGATA & Y.ATOMI
The molecular chaperone HSP47 rapidly senses gravitational
changes in myoblasts.
Genes Cells. 11 ,1253-1265(2006)
・A. KITAMURA, H. KUBOTA, C. PACK, G.MATSUMOTO, S. HIRAYAMA,
Y. TAKAHASHI, H. KIMURA, M. KINJO, R. MORIMOTO & K. NAGATA
Cytosolic chaperonin prevents polyglutamine toxicity with altering
the aggregation state.
Nature Cell Biol. 8 (10):1163-1169(2006)
・S. KUBOTA, H. KUBOTA & K. NAGATA
Cytosolic chaperonin protects folding intermediates of Gbeta from
aggregation by recognizing hydrophobic beta-strandsc.
Proc. Natl. Acad. Sci. USA, 103 (22):8360-8365(2006)
・Y. ISHIDA, H. KUBOTA, A.YAMAMOTO, A. KITAMURA, H.P.BACHINGER
& K.NAGATA
Type I collagen in Hsp47-null cells is aggregated in ER and
deficient in N-propeptide processing and fibrillogenesis.
Mol. Biol. Cell. 17 :2346-2355(2006)
・T,KOIDE, Y.NISHIKAWA, S.ASADA, C.M.YAMAZAKI, Y.TAKAHARA, DL.HOMMA,
A.OTAKA, N.WAKAMIYA, K.NAGATA & K.KITAGAWA
Specific recognition of the collagen triple helix by chaperone
HSP47.II. The HSP47-binding structural motif in collagens and
related proteins.
J. Biol. Chem. 281 (16):11177-11185(2006)
・K.HIRAI, S.KIKUCHI, A.KURITA, S.OHASHI, E.ADACHI, Y.MATSUOKA, K.NAGATA
& M.WATANABE
Immunohistochemical distribution of heat shock protein 47
(HSP47) in scirrhous carcinoma of the stomach.
Anticancer Research 26 :71-78(2006)
・N.HOSOKAWA, I.WADA, Y.NATSUKA & K.NAGATA
EDEM accelerates ERAD by preventing aberrant dimer formation
of misfolded alpha1-antitrypsin.
Genes Cells.11 (15)465-476(2006)
・K.HIRAO, Y.NATSUKA, T.TAMURA, I.WADA, D.MORITO, S.NATSUKA, P.ROMERO,
B.SLENO, L.O.TREMBLAY, A.HERSCOVICS, K.NAGATA & N.HOSOKAW
EDEM3, a soluble EDEM homolog, enhances glycoprotein ERAD and
mannose trimming.
J. Biol. Chem. 281 (14):9650-9658(2006)
・Y.ODA, T.OKADA, H. YOSHIDA, R.J.KAUFMAN, K.NAGATA & K.MORI
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
protein response and are required for ER-associated degradation.
J. Cell. Biol.172 (3):383-393(2006)
・T,KOIDE, S.ASADA, Y.TAKAHARA, Y.NISHIKAWA, K.NAGATA & K.KITAGAWA
Specific recognition of the collagen triple helix by chaperone
HSP47.Minimal structural requirement and spatial molecular
orientation.
J. Biol. Chem.281 (6):3432-3438(2005)
・F.KANO, H.KONDO, A.YAMAMOTO, Y.KANEKO, K.UCHIYAMA,N.HOSOKAWA,
K.NAGATA, M.MURATA
NSF/SNAPs and p97/p47/VCIP135 are sequentially required
for cell cycle-dependent reformation of the ER network.
Genes Cells.10 (10):989-999(2005)
・T.YOSHINAGA, K.NAKATOME, J.NOZAKI, M.NAITOH, J.HOSEKI, H.KUBOTA,
K.NAGATA & A.KOIZUMI
Proinsulin lacking the A7-B7 disulfide bond, Ins2 Akita, tends
to aggregate due to the exposed hydrophobic surface.
Biol. Chem.386 (11):1077-1085(2005)
・M.NAITOH, H.KUBOTA, M.IKEDA, T.TANAKA, H.SIRANE, S.SUZUKI & K.NAGATA
Gene expression in human keloids is altered from dermal to
chondrocytic and osteogenic lineage.
Genes Cells.10 (11):1081-1091(2005)
・F.KANO, H.KONDO, A.YAMAMOTO, AR.TANAKA, N.HOSOKAWA, K.NAGATA,
&M.MURATA.
The maintenance of the endoplasmic reticulum network is
regulated by p47, a cofactor of p97, through phosphorylation by
cdc2 kinase.
Genes Cells. 10 (4):333-344(2005)
・T.KOIDE & K.NAGATA
Collagen Biosynthesis.
Topics in Current Chemistry 247 :Collagen(EdsBrinckmann et al.)Springer-Verlag,
pp.85-114(2005)
・H.KUBOTA & K.NAGATA
Roles of collagen fibers and its specific molecular chaperone
: analysis using HSP47-knockout mice.
Biol Sci Space.18 (3):118-119(2004)
・S.J.MARCINIAK, C.Y.YUN, S.OYADOMARI, I.NOVOA, Y.ZHANG, R.JUNGREIS,
K.NAGATA,H.P.HARDING & D.RON
CHOP induces death by promoting protein synthesis and oxidation
in thestressed endoplasmic reticulum.
Genes Develop.18 (24):3066-3077(2004)
・T.MARUTANI, A.YAMAMOTO, N.NAGAI, H.KUBOTA & K.NAGATA
Accumulation of type IV collagen in dilated endoplasmic reticulum
leads to apoptosis HSP47-knockout mouse embryos through the
induction of CHOP.
J.Cell.Sci.117 :5913-5922(2004)
・M.YAMASHITA, K.HIRAYOSHI & K.NAGATA
Characterization of multiple members of the HSP70 family in
platyfishculture cells: molecular evolution of stress protein HSP70
in vertebrates.
Gene 336 :207-218(2004)
・Y.MATSUOKA, H.KUBOTA, E.ADACHI, N.NAGAI, T.MARUTANI, N.HOSOKAWA
& K.NAGATA
Insufficient folding of type IV collagen nad formation of abnormal
basement membrane-like structure in embryoid bodies derived
from HSP47-null ES cells.
Mol. Biol. Cell.15 :4467-4475 (2004)
・S.OHASHI, H.ABE, T.TAKAHASHI, Y.YAMAMOTO, M.TAKEUCHI, H.ARAI,
K.NAGATA, T.KITA, H.OKAMOTO, H.YAMAMOTO, T.DOI
Advanced glycation end products increase collagen-specific
chaperone protein in mouse diabetic nephropathy.
J. Biol. Chem.279 (19):19816-19823(2004)
・J.NOZAKI, H.KUBOTA, H.YOSHIDA, M.NAITOH, J.GOJO, T.YOSHINAGA,
K.MORI, A.KOIZUMI & K.NAGATA
The endoplasmic reticulum stress response is stimulated through
the continuous activation of transcription factors ATF6 and XBP1
in Ins2+/Akita pancreatic beta cells.
Genes Cells9 :261-270(2004)
・K.NAGATA
HSP47 as a collagen-specific molecular chaperone:function and
expression in normal mouse development.
Seminars in Cell and Developmental Biology 14:275-282 (2003)
・Y.YAMAZAKI, H.KUBOTA, M.NOZAKI & K.NAGATA
Transcriptional regulation of the cytosolic chaperonin theta
subunit gene, Cctq, by Ets domain transcription factors Elk-1,
Sap-1a, and Net in the absence of serum response factor.
J. Biol. Chem.278 (33):30642-30651 (2003)
・N.HOSOKAWA, L.O.TREMBLAY, Z.YOU, A.HERSCOVICS, I,WADA & K.NAGATA
Enhancement of endoplasmic reticulum (ER) degradation of
misfolded Null Hong Kong alpha1-antitrypsin by human ER
mannosidase I.
J. Biol. Chem.278 (28):26287-26294(2003)
・S.YOKOTA, H.KUBOTA, Y.MATSUOKA, M.NAITOH, D.HIRATA, S.MINOTA,
H.TAKAHASHI, N.FUJII & K.NAGATA
Prevalence of HSP47 antigen and autoantibodies to HSP47 in
the sera of patients with mixed connective tissue disease.
Biochem Biophys Res Commun.303 :413-418(2003)
・Y.ODA, N.HOSOKAWA,I .WADA & K.NAGATA
EDEM as an acceptor of terminally misfolded glycoproteins
released from calnexin.
Science299 (5611):1394-1397(2003)
・H.YOSHIDA, T.MATSUI, N.HOSOKAWA, R.J.KAUFMAN, K.NAGATA & K.MORI
A.time-dependent phase shift in the mammalian unfolded proten
response.
Develop. Cell. 4 (2):265-271(2003)
・N.YASUI, T.MORI, D.MORITO,O.MATSUSHITA, H.KOURAI, K.NAGATA, T.KOIDE
Dual-site recognition of different extracellular matrix components
by anti-angiogenic / neurotrophic serpin, PEDF.
Biochemistry.42 (11):3160-3167(2003)
・K.YASUDA, K.HIRAYOSHI, H.HIRATA, H.KUBOTA, N.HOSOKAWA & K.NAGATA
The Kruppel-like factor Zf9 and proteins in the Sp1 family
regulate the expression of HSP47, a collagen-specific molecular.
J. Biol Chem.277 (47):44613-44622(2002)
・K.SATO, K.YOMOGIDA, T.WADA, T.YORIHUZI, Y.NISHIMUNE, N.HOSOKAWA
&K.NAGATA
Type XXVI collagen, a new member of the collagen family,
is specifically expressed in the testis and ovary.
J. Biol Chem.277 (40):37678-37684(2002)
・N.HOSOKAWA & K.NAGATA
α-mannosidase-like protein involved in quality control in
the endoplasmic reticulum(ER).
Glycoforum websiteﾓBeyond glycogens (Ed. N.Taniguchi) Seikagaku Corporation,6(2002)
・J.NISHIZAWA,A.NAKAI,M.KOMEDA,T.BAN & K.NAGATA
Increased preload directly induces the activation of heat shock
transcription factor 1 in the left ventricular overloaded heart.
Cardiovas. Res.55 (2):341-348(2002)
・T.KOIDE,Y.TAKAHARA,S.ASADA & K.NAGATA
Xaa-Arg-Gly triplets in the collagen triple-helix are dominant
binding sites for the molecular chaperone HSP47.
J. Biol. Chem.277 (8):6178-6182(2002)
・T. KOIDE,Y.TAKAHASHI,S.ASADA, K. NAGATA & Y.ITO
Substrate recognition of collagen-specific molecular chaperone
HSP47:contribution of arginine residue in the triple helical
substrates.
Peptide Science2000 (Ed.T. Shioiri)The Japanese Peptide Society,
pp.159-162(2001)
・K.NAKATSUKASA,S.NISHIKAWA,N.HOSOKAWA,K.NAGTA & T.ENDO
Mnl1p,an alpha-mannosidase-like protein in yeast Saccaromyces
cerevisiae,is required for ER associated degradation of
glycoproteins.
J. Biol. Chem.276 (12):8635-8638(2001)
・N.HOSOKAWA,I.WADA,K.HASEGAWA,T.YORIHUZI,L.O.TREMBLAY, A.HERSCOVICS
& K.NAGATA
A novel ER alpha-mannosidase-like protein accelerates
ER-associated degradation.
EMBO Reports2 (5):415-422(2001)
・M.NAITOH, N.HOSOKAWA, H.KUBOTA, T.TANAKA, H.SHIRANE, M.SAWADA,
Y.NISHIMURA & K.NAGATA
Upregulation of HSP47 and collagen type III in the dermal fibrotic
desease, keloid.
Biochem Biophys Res Commun.280 :1316-1322(2001)
・O.MATSUSHITA, T.KOIDE, R.KOBAYASHI, K.NAGATA & A.OKABU
Substrate recognition by the collagen-binding domain of
clostridium histolyticum class I collagenase.
J. Biol. Chem.276 (12):8761-8770(2001)
・M.KIKUCHI, C.TAKEDA, Y.TSUJIMOTO, S.ASADA & K.NAGATA
A single chain Fv fragment 2A3 specific for native
lysozyme:Isolation from a human synthetic phage display antibody
library and characterization.
J. Biochem.129 :237-242(2001)
・M.MATSUDA, T.KOIDE, T.YORIHUZI, N.HOSOKAWA & K.NAGATA
Moleular cloning of a novel ubiquitin-like protein,UBIN,that binds to
ER targeting signal sequences.
Biochem Biophys Res Commun.280 :535-540(2001)
・S.MURAKAMI, Y.TODA, T.SEKI, E.MUNETOMO, Y.KONDO,
T.SAKURAI,Y.FUKUKAWA, M.MATSUYAMA, T.NAGATE, N.HOSOKAWA
& K.NAGATA
Heat shock protein(HSP)47 and collagen are upregulated during
neointimal formation in the balloon-injured rat carotid artery.
Atherosclerosis157 :361-368(2001)
・YOKOTA, S., YANAGI, H., YURA, T. AND KUBOTA, H.
Cytosolic chaperonin CCT changes contents of particular subunit
sepecies concomitant with substrate binding and folding activities
during the cell cycle.
Eur. J. Biochem.268, 4664-4673. (2001)
・YOKOTA, S., YAMAMOTO, Y., SHIMIZU, K., MOMOI, H., KAMIKAWA, T.,
YAMAOKA, Y., YANAGI, H., YURA, T. AND KUBOTA, H.
Increased expression of cytosolic chaperonin CCT in human
hepatocellular and colonic carcinoma.
Cell Stress & Chaperones6, 345-350. (2001)
・J.NISHIZAWA & K.NAGATA
Induction of heat-shock proteins in ischemic heart and myocardial
protection.
" Thermotherapy for Neoplasia, Inflammation, and Pain" (Eds.M.Kosaka et al.)
Springer pp382-391(2000)
・N.NAGAI, M.HOSOKAWA, S.ITOHARA, E.ADACHI, T.MATSUSHITA, N.HOSOKAWA & K.NAGATA
Embryonic lethality of molecular chaperone hsp47 knockout mice
is associated with defects in collagen biosynthesis.
J. Cell Biol.150 (6):1499-1506 (2000)
・ T.KOIDE, A.ASO, T.YORIHUZI, & K.NAGATA
Conformational requirements of collagenous peptides for
recognition by the chaperone protein HSP47.
J. Biol. Chem.275 (36):27957-27963 (2000)
・K.NAGATA
Significance of the real-time analysis of biological interactions.
" Real-Time Analysis of Biomolecular Interactions" (Eds.K.Nagata & H.Handa)
Springer 2000,pp3-9.
・H. KARAHASHI, K. NAGATA, K. ISHII & H. AMANO
A selective inhibitor of p38 MAP kinase, SB202190, induced
apoptotic cell death of a lipopolysaccharide-treated macrophage-
like cell line,J774.1
Biochim. Biophys. Acta1502 :207-223(2000)
・S.YOKOTA,M KITAHARA & K.NAGATA
Benzylidene lactam compound, KNK437, a novel inhibitor of
acquisition of thermotolerance and heat shock protein induction in
human colon carcinoma cells.
Cancer Research60 :2942-2948(2000)
・T. KOIDE,S. ASADA & K. NAGATA
Interaction of collagen-specific molecular chaperone HSP47 with
collagen-model peptides
Peptide Science1999 (Ed.N. Fujii)The Japanese Peptide Society,pp.17-20(2000)
・N. HOSOKAWA & K. NAGATA
Procollagen binding to both prolyl 4-hydroxylase/protein disulfide
isomerase and HSP47 within the endoplasmic reticulum in the
absence of ascorbate.
FEBS. Letters.466 (1):19-25 (2000)
・J. NISHIZAWA & K. NAGATA
Ischemia/reperfusion injury and heat shock proteins.
" Heat Shock Proteins in Myocardial protection" Medial IntelligenceUnit16
Landes Bioscience. pp.121-134(2000)
・K.ABE, Y.OZONO, M.MIYAZAKI, T.KOJI, K.SHIOSHITA, A.FURUSU,
S.TSUKASAKI, F.MATSUYA, N.HOSOKAWA, T.HIRADA, T.TAGUCHI, K.NAGATA
& S.KOHNO
Interstitial expression of heat shock protein 47 and alpha-smooth
muscle actin in renal allograft failure.
Nephrol Dial Transplant 15 (4):529-535(2000)
・ KUBOTA, H., YOKOTA, S., YANAGI, H. AND YURA, T.
Transcriptional regulation of the mouse cytosolic chaperonin
subunit gene Ccta/t-conplex polypeptide 1 by selenocysteine
tRNA subunit gene transcription factor family zinc finger proteins.
J. Biol. Chem.275 , 28641-28648. (2000)
・YOKOTA, S., YANAGI, H., YURA, T. AND KUBOTA, H.
Upregulation of cytosolic chaperonin CCT subunits during recovery
from chemical stress that causes accumulation of unfolded
proteins.
Eur. J. Biochem.267, 1658-1664. (2000)
・YOKOTA, S., HIRATA, D., MINOTA, S., HIGASHIYAMA, T., KURIMOTO, M.,
YANAGI, H., YURA, T. & KUBOTA, H.
Autoantibodies against cytosolic chaperonin CCT in human sera
with rheumatic autoimmune diseases: comparison with antibodies
against other HSP60 family proteins.
Cell Stress Chaperones5, 337-346. (2000)
・YOKOTA, S., KAYANO, T., OHTA T., KURIMOTO, M., YANAGI, H., YURA, T.
& KUBOTA, H.
Proteasome-dependent degradation of cytosolic chaperonin CCT.
Biochem. Biophys. Res. Commun.279, 712-717. (2000)