・  原著論文 / Original articles


・  1996〜1999

    M. TOMITA, K. YOSHIZATO, K. NAGATA & T. KITAJIMA
      Enhancement of secretion of human procollagen I in mouse
     HSP47-expressing insect cells.

      J. Biochem. 126 (6):1118-1126 (1999)

    H. HIRATA, I. YAMAMURA, K. YASUDA, A. KOBAYASHI, H. TADA, M. SUZUKI,
      K. HIRAYOSHI, N. HOSOKAWA & K. NAGATA
      Separate cis-acting DNA elements control cell type- and
     tissue-specific expression of collagen-binding molecular chaperone
     HSP47.

      J. Biol. Chem. 274 (50): 35703-35710 (1999)

    T. KOIDE, S. ASADA & K. NAGATA
      Substrate recognition of collagen-specific molecular chaperone
     HSP47: Structural requirements and binding regulation.

      J. Biol. Chem. 274 (49):34523-34526 (1999)

    Y. KAWAZOE, M. TANABE, N. SASAI, K. NAGATA & A. NAKAI
      HSF3 is a major heat shock responsive factor during chicken
     embryonic development.

      Eur.J. Biochem. 265 (2):688-697 (1999)

    M. TANABE, N. SASAI, K. NAGATA, X-D. LIU, P. C. C. LIU, D. J. THIELE
      & A. NAKAI.
      The mammalian HSF4 gene generates both an activator and
     a repressor of heat shock genes by alternative splicing.

      J. Biol. Chem. 274 (39):27845-27856 (1999)

    S. ASADA, T. KOIDE, H. YASUI & K. NAGATA
      Effect of HSP47 on prolyl 4-hydroxylation of collagen model
     peptides.

      Cell Struct. Funct. 24 (4):187-196 (1999)

    M. YOSHIDA, T. ENDO, K. ITO, N. HOSOKAWA & K.NAGATA
      Dynamics and regulation of the stress response: Meeting report
     on stress response and molecular chaperones at Kyoto.

      Cell Stress & Chaperones. 4 (1):66-74 (1999)

    N. NAGAI, T. YORIHUZI, N. HOSOKAWA & K.NAGATA
      The human genome has a functional hsp47 gene (CBP2) and
     pseudogene (pshsp47).

      Gene. 227(2):241-248 (1999)

    J. NISHIZAWA, A. NAKAI, K. MATSUDA, T. BAN & K. NAGATA
      Reactive Oxygen Species Play an Important Role in the Activation
     of Haet Shock Factor 1 in Ischemia-Reperfused Heart.

      Circulation. 99(7):934-941 (1999)

    J. NISHIZAWA & K. NAGATA
      Regulation of heat shock transcription factors by hypoxia or
     ischemia/reperfusion in the heart and brain.

      Handbook of Experimental Pharmacology " Stress Proteins" Volume 136
      (Ed. Latchman. D.S.)
Springer-Verlag 1999., pp.201-224.

    YOKOTA, S., YANAGI, H., YURA, T. AND KUBOTA, H.
      Cytosolic chaperonin is up-regulated during cell growth:
     preferential expression and binding to tubulin at G(1)/S transition
     through early S phase.

      J. Biol. Chem. 274, 37070-37078. (1999)

    KUBOTA, H., YOKOTA, S., YANAGI, H. AND YURA, T.
      Structures and co-regulated expression of the genes encoding
     mouse cytosolic chaperonin CCT subunits.

      Eur. J. Biochem. 262, 492-500. (1999)

    KUBOTA, H., MATSUMOTO, S., YOKOTA, S., YANAGI, H. AND YURA, T.
      Transcriptional activation of mouse cytosolic chaperonin CCT
     subunit gene by heat shock factors HSF1 and HSF2.

      FEBS Lett. 461, 125-129.(1999)

    T. KOIDE & K. NAGATA
      HSP47, A molecular chaperone which Interacts with procollagens
     in the endoplasmic reticulum.

      Connective Tissue.30(4):307-314 (1998)

    H.MASUDA, N. HOSOKAWA & K. NAGATA
      Expression and localization of collagen-binding stress protein
     HSP47 in mouse embryo development : Comparison with types I
     and II collagen.

      Cell Stress & Chaperones. 3(4):256-264 (1998)

    B. CAI, A. TOMIDA, K. MIKAMI, K. NAGATA & T. TSURUO
      Down-Regulation of epidermal growth factor receptor-signaling
     pathway by binding of GRP78/BiP to the receptor under glucose
     -starved stress conditions.

      J. Cell Physiol. 177:282-288 (1998)

    Y. KAWAZOE, A. NAKAI, M. TANABE & K. NAGATA
      Proteasome inhibition leads to the activation of all members of
     the heat-shock-factor family.

      Eur. J. Biochem. 255:356-362 (1998)

    M. SUNAMOTO, K. KUZE, H. TSUJI, N. OHISHI, K. YAGI, K. NAGATA, T. KITA
      & T. DOI
      Antisense oligonucleotides against collagen-binding stress protein
     HSP47 suppress collagen accumulation in experimental
     glomerulonephritis.

      Lab. Invest. 78(8):967-972 (1998)

    N. HOSOKAWA, M. SATOH, C. HOHENADLE, K. Kuhn & K. NAGATA
      HSP47, a collagen-specific molecular chaperone, delays the
     secretion of type III procollagen transfected in human embryonic
     kidney cell line 293.
     A possible role for HSP47 in collagen modification.

      J. Biochem. 124(3):654-662 (1998)

    M.SUNAMOTO, K. KUZE, N. IEHARA, H. TAKEOKA, K. NAGATA, T. KITA & T. DOI
      Expression of heat shock protein 47 is increased in remnant kindey
     and correlates with disease progression.

      Int J Exp Pathol. 79(3):133-140 (1998)

    T. MORIYAMA, N. KAWADA, A. ANDO, A. YAMAUCHI, M. HORIO, K. NAGATA,
      E. IMAI & M HORI
      Up-regulation of HSP47 in the mouse kidneys with unilateral
     ureteral obstruction.

      Kidney Int. 54:110-119 (1998)

    I.YAMAMURA, H. HIRATA, N. HOSOKAWA & K.NAGATA
      Transcriptional activation of the mouse HSP47 gene in mouse
     osteoblast MC3T3-E1 cells by TGF-beta1.

      Biochem Biophys Res Commun. 244:68-74 (1998)

    M. TANABE, Y. KAWAZOE, S. TAKEDA, R. I. MORIMOTO, K. NAGATA & A. NAKAI
      Disruption of the HSF3 gene results in the severe reduction of
     heat shock gene expression and loss of thermotolerance.

      EMBO J. 17(6):1750-1758 (1998)

    K. NAGATA, T. KOIDE, H. HIRATA, N. NAGAI, M. SATOH, N. HOSOKAWA
      Role of molecular chaperone HSP47 in the synthesis and secretion
     of procollagens.

      THE 1996TANIGUCHI INTERNATIONAL SYMPOSIUM " From Molecules to Man
     : Frontiers in Cell Biology ".
(1997)

    K.NAGATA
      Expression and function of HSP47 : a collagen-specific molecular
     chaperone in the endoplasmic reticulum.

      Matrix Biology. 16:379-386 (1997)

    T. MORIYAMA, N. KAWADA, Y. AKAGI, A. ANDO, M. HORIO, A. YAMAUCHI,
      K.NAGATA, E. IMAI & M. HORI
      TCV-116 inhibits interstitial fibrosis and HSP47 mRNA in rat
     obstructive nephropathy.

      Kidney Int. 52:232-235 (1997)

    N. WATANABE, N. TSUJI, S. AKIYAMA, H. SASAKI, T. OKAMOTO,
      D. KOBAYASHI, T. SATO, T. HAGINO, N. YAMAUCHI, Y. NIITSU, A. NAKAI
      & K. NAGATA
      Induction of heat shock protein 72 synthesis by endogenous tumor
     necrosis factor via enhancement of the heat shock element
     -binding activity of heat shock factor 1.

      Eur. J. Immunol. 27:2830-2834 (1997)

    T. NOGUCHI, K. CHIN, M. OHI, H. KITA, N. OTSUKA, T. TSUBOI, M. SATOH,
      A. NAKAI, K. KUNO & K. NAGATA
      Heat shock protein 72 level decreases during sleep in patients with
     obstructive sleep apnea syndrome.

      Am J Respir Crit Care Med. 155:1316-1322 (1997)

    M. TANABE, A. NAKAI, Y. KAWAZOE, & K. NAGATA
      Different thresholds in the responses of two heat shock
     transcription facrors, HSF1 and HSF3.

      J. Biol. Chem. 272:15389-15395 (1997)

    D. WALSH, Z. LI, Y. WU, & K.NAGATA
      Heat shock and the role of the HSPs during neural plate induction
     in early mammalian CNS and brain development.

      Cell Mol Life Sci. 53 (2):198-211 (1997)

    K. NAGATA, M. SATOH, A.MILLER & N. HOSOKAWA
      Involvement of HSP47 in the folding and processing of procollagen
     in the endoplasmic reticulum.

      Molecular Chaperones in Proteins; Structure, Function, and Mode of Action.
     (Eds. Fink A L, Goto Y),
Marcel Dekker, 1997, 10 pp.225-240

    T. WAKAMIYA, R. TOGASHI, T. NISHIDA, K. SARUTA, J. YASUOKA,
      S. KUSUMOTO, S. AIMOTO, K. Y. KUMAGAYE, K. NAKAJIMA & K.NAGATA
      Synthetic study of phosphopeptides related to heat shock protein
     HSP27.

      Bioorg & Med Chem. 5 (1):135-145 (1997)

    A. NAKAI, M. TANABE, Y. KAWAZOE, J. INAZAWA, R. I. MORIMOTO & K.NAGATA
      HSF4, a new member of the human heat shock factor family which
     lacks properties of a transcriptional activator.

      Mol. Cell. Biol. 17 (1):469-481 (1997)

    KUBOTA, H., HYNES, G. M., KERR, S. M., AND WILLISON, K. R.
      Tissue-specific subunit of the mouse cytosolic chaperonin
     -containing TCP-1.

      FEBS Lett. 402, 53-56. (1997)

    Y. TANAKA, K. KOBAYASHI, M. KITA, H. MASUDA, S. KINOSHITA, K. NAGATA,
      J . IMANISHI
      Expression of 47 kDa heat shock protein (HSP47) during
     development of mouse cornea.

      Exp Eye Res 63: 383-393 (1996)

    K. NAGATA & N.HOSOKAWA
      Regulation and function of collagen-specific molecular chaperone,
     HSP47.

      Cell Structure and Function. (Dynamics of the Cell) 21(5):425-430 (1996)

    J. NISHIZAWA, A. NAKAI, T. HIGASHI, M. TANABE, S. NOMOTO, K. MATSUDA,
      T. BAN & K. NAGATA
      Reperfusion causes significant activation of heat shock
     transcription factor 1 in ischemic rat heart.

      Circulation. 94 (9):2185-2192 (1996)

    K. NAGATA
      Regulation of thermotolerance and ischemic tolerance.
      Stress-Inducible Cellular Responses (Eds.U. Feige, R. I. Morimoto, I. Yahara, B.S. Polla ),
      Birkhauser, 1996, pp. 467-481.

    N. KAWADA, T. KUROKI, K. KOBAYASHI, M. INOUE, K. NAKATANI, K. KANEDA
      & K. NAGATA
      Expression of heat-shock protein 47 in mouse liver.
      Cell Tissue Res. 284:341-346 (1996)

    M. SATOH, K. HIRAYOSHI, S. YOKOTA, N. HOSOKAWA & K. NAGATA
      Intracellular interaction of collagen-specific stress protein HSP47
     with newly synthesized procollagen.

      J. Cell Biol. 133(2):469-483 (1996)

    T. S. H. EL-THAHER, A. F. DRAKE, S. YOKOTA, A. NAKAI, K. NAGATA
      & A. D. MILLER
      The pH-dependent, ATP-independent interaction of collagen
     specific serpin/stress protein HSP47.

      Prot Pept Lett.3 (1):1-8 (1996)

    K. NAGATA
      HSP47: a collagen-specific molecular chaperone in the
     endoplasmic reticulum.

      TiBS.(Trends in Biochemical Sciences)21(1):22-26 (1996)



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