Laboratory of Cell Signaling and Development (CSD Lab)

Department of Molecular Biosceinces, Faculty of Life Sciences

Kyoto Sangyo University


Listed are only those viewable at PubMed or other internet resources

This list includes publications before 2007


72: Tokmakov AA, Iguchi S, Iwasaki T, Fukami Y, Sato KI.

Global decay of mRNA is a hallmark of apoptosis in aging Xenopus eggs.

RNA Biol.[Epub ahead of print]


71: Tokmakov, A.A., Iwasaki, T., Sato, K., Kamada, S.

Programming of somatic cells and nuclei by Xenopus oocyte and egg extracts.

International Journal of Developmental Biology, June 1 [Epub ahead of print]

70: Sato, K.

Fertilization and Protein-tyrosine Kinase Signaling: Are They Merging or Emerging? In Reproductive and Developmental Strategies (Kobayashi, Kitano, Iwao, and Kondoh eds. Animal Diversity and Generality series, Springer) in press.


69: Sato, K.

Transmembrane signal transduction in oocyte maturation and fertilization: focusing on Xenopus laevos as a model animal.

International Journal of Molecular Sciences 16, 114-134.

68: Tokmakov, A.A., Stefanov, V.E., Iwasaki, T., Sato, K., Fukami,Y.

Calcium Signalling and Meiotic Exit at Fertilization in Xenopus egg.

International Journal of Molecular Sciences 15, 18659-18676.

67: Iwao, Y., Shiga, K., Shiroshita, A., Yoshikawa, T., Sakiie, M., Ueno, T., Ueno, S., Ijiri, T.W., Sato, K.

The need of MMP-2 on the sperm surface for Xenopus fertilization: Its role in a fast electrical block to polyspermy.

Mech. Dev. in press

66: Mahbub Hasan, A.K.M., Hashimoto, A., Maekawa, Y., Matsumoto, T., Kushima, S., Ijiri, T.W., Fukami, Y., Sato, K.

The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.

Development 141, 1705-1714.

  1. 65.Ijiri, T.W., Kishikawa, J., Imamura, H., Iwao. Y., Yokoyama, K., Sato, K.

ATP imaging in Xenopus laevis oocytes.

In Sexual Reproduction in Animals and Plants, pp. 181-186. (Springer)

64: Sato K., Mahbub Hasan, A.K.M., Ijiri, T.W.

Focused proteomics on egg membrane microdomains to elucidate the cellular and molecular mechanisms of fertilization in the frog Xenopus laevis.

In Sexual Reproduction in Animals and Plants, pp. 157-170. (Springer)


63: Sato K.

Cellular Functions Regulated by Phsophorylation of EGFR on Tyr845.

International Journal of Molecular Sciences 14, 10761-10790.


62: Kihira S, Yoshida J, Kawada Y, Hitomi Y, Asada T, Hisatomi R, Ohta A, Iwasaki T, Mahbub Hasan AKM, Fukami Y, Sato K.

Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells.

Biology Open 1, 1024-34.

61: Ijiri TW, Mahbub Hasan AKM, Sato K.

Protein-tyrosine kinase signaling in the biological functions associated with sperm.

Journal of Signal Transduction 2012, 181560.

60: Mahbub Hasan AKM, Ijiri T, Sato K.

Involvemnet of Src in the adaptation of cancer cells under microenvironmental stresses.

Journal of Signal Transduction 2012, 483796.

59: Mahbub Hasan AKM, Matsumoto T, Kihira S, Yoshida J, Sato K

Phospho-signaling at oocyte maturation and fertilization: Set up for embryogenesis and beyond Part II. Kinase regulators and substrates.

In Embryogenesis pp.499-554 (On-line book published by InTech Open Access Publisher)

58: Mahbub Hasan AKM, Matsumoto T, Kihira S, Yoshida J, Sato K

Phospho-signaling at oocyte maturation and fertilization: Set up for embryogenesis and beyond. Par I. Protein kinases.

In Embryogenesis pp. 447-498 (On-line book published by InTech Open Access Publisher)


57: Nakai M, Ito J, Sato K, Noguchi J, Kaneko H, Kashiwazaki N, Kikuchi K.

Pre-treatment of sperm reduces success of intracytoplasmic sperm injection in the pig.

Reproduction 142, 285-293. 

56: Mahbub Hasan AKM, Fukami Y, Sato K.

Gamete membrane microdomains and their associated molecules in fertilization signaling.

Mol. Reprod. Dev. 78, 814-830.

55: Kushima S, Mammadova G, Mahbub Hasan AKM, Fukami Y, Sato K.

Characterization of lipovitellin 2 as a tyrosine-phosphorylated protein in oocytes, eggs, and early embryos of Xenopus laevis.

Zool Sci. 28, 550-559.


54: Tokmakov AA, Iwasaki T, Sato K, Fukami Y.

Analysis of signal transduction in cell-free extracts and rafts of Xenopus eggs.

Methods. 2010 May;51(1):177-82. Epub 2010 Jan 15. Review. PubMed PMID: 20079845.


53: Mammadova G, Iwasaki T, Tokmakov AA, Fukami Y, Sato K.

Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.

BMC Dev Biol. 2009 Dec 17;9:68. PubMed PMID: 20015408; PubMed Central PMCID: PMC2805626.

52: Oka M, Sumita N, Sakaguchi M, Iwasaki T, Bito T, Kageshita T, Sato K, Fukami Y, Nishigori C.

12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by  inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s).

J Biol Chem. 2009 Oct 30;284(44):30416-23. Epub 2009 Sep 15. PubMed PMID:19755418; PubMed Central PMCID: PMC2781596.


51: Sato K.

Signal transduction of fertilization in frog eggs and anti-apoptotic mechanism in human cancer cells: common and specific functions of membrane microdomains.

Open Biochem J. 2008;2:49-59. Epub 2008 Apr 29. PubMed PMID: 18949075; PubMed Central PMCID: PMC2570554.

50: Iwasaki T, Koretomo Y, Fukuda T, Paronetto MP, Sette C, Fukami Y, Sato K.

Expression, phosphorylation, and mRNA-binding of heterogeneous nuclear ribonucleoprotein K in Xenopus oocytes, eggs, and early embryos.

Dev Growth Differ. 2008 Jan;50(1):23-40. PubMed PMID: 18042150.


49: Kurokawa M, Yoon SY, Alfandari D, Fukami K, Sato K, Fissore RA.

Proteolytic processing of phospholipase Cz and [Ca2+]i oscillations during mammalian fertilization.

Dev Biol. 2007 Dec 1;312(1):407-18. Epub 2007 Sep 29. PubMed PMID:18028898; PubMed Central PMCID: PMC2254324.

48: Ueda Y, Imaizumi C, Kubo H, Sato K, Fukami Y, Iwao Y.

Analysis of terminal sugar moieties and species-specificities of acrosome reaction-inducing substance in Xenopus (ARISX).

Dev Growth Differ. 2007 Sep;49(7):591-601. Epub 2007 Jul 17. PubMed PMID: 17635533.

47: Mahbub Hasan AK, Ou Z, Sakakibara K, Hirahara S, Iwasaki T, Sato K, Fukami Y.

Characterization of Xenopus egg membrane microdomains containing uroplakin Ib/III complex: roles of their molecular interactions for subcellular localization and signal transduction.

Genes Cells. 2007 Feb;12(2):251-67. PubMed PMID: 17295843.


46: Yamamoto N, Mammadova G, Song RX, Fukami Y, Sato K.

Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.

J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33. Epub 2006 Oct 24. PubMed PMID: 17062641.

45: Sato K, Yoshino K, Tokmakov AA, Iwasaki T, Yonezawa K, Fukami Y.

Studying fertilization in cell-free extracts: focusing on membrane/lipid raft functions and proteomics.

Methods Mol Biol. 2006;322:395-411. Review. PubMed PMID:16739739.

44: Sato K, Fukami Y, Stith BJ.

Signal transduction pathways leading to Ca2+ release in a vertebrate model system: lessons from Xenopus eggs.

Semin Cell Dev Biol. 2006 Apr;17(2):285-92. Epub 2006 Mar 2. Review. PubMed PMID: 16584903.

43: Iwasaki T, Sato K, Yoshino K, Itakura S, Kosuge K, Tokmakov AA, Owada K, Yonezawa K, Fukami Y.

Phylogeny of vertebrate Src tyrosine kinases revealed by the epitope region of mAb327.

J Biochem. 2006 Mar;139(3):347-54. PubMed PMID: 16567399.

42: Hadiarto T, Nanmori T, Matsuoka D, Iwasaki T, Sato K, Fukami Y, Azuma T, Yasuda T.

Activation of Arabidopsis MAPK kinase kinase (AtMEKK1) and induction of AtMEKK1-AtMEK1 pathway by wounding.

Planta. 2006 Mar;223(4):708-13. Epub 2005 Oct 7. PubMed PMID: 16211390.


41: Mahbub Hasan AK, Sato K, Sakakibara K, Ou Z, Iwasaki T, Ueda Y, Fukami Y.

Uroplakin III, a novel Src substrate in Xenopus egg rafts, is a target for sperm protease essential for fertilization.

Dev Biol. 2005 Oct 15;286(2):483-92. Epub 2005 Sep 15. PubMed PMID: 16168405.

40: Kurokawa M, Sato K, Wu H, He C, Malcuit C, Black SJ, Fukami K, Fissore RA.

Functional, biochemical, and chromatographic characterization of the complete [Ca2+]i oscillation-inducing activity of porcine sperm.

Dev Biol. 2005 Sep 15;285(2):376-92. PubMed PMID: 16098961.

39: Sakakibara K, Sato K, Iwasaki T, Kitamura K, Fukami Y.

Generation of an antibody specific to Xenopus fertilized eggs by subtractive immunization.

Genes Cells. 2005 Apr;10(4):345-56. PubMed PMID: 15773897.

38: Sato K, Iwasaki T, Fukami Y.

Association of c-Src with p52Shc in mitotic NIH3T3 cells as revealed by Src-Shc binding site-specific antibodies.

J Biochem. 2005 Jan;137(1):61-7. PubMed PMID: 15713884.

37: Sakakibara K, Sato K, Yoshino K, Oshiro N, Hirahara S, Mahbub Hasan AK, Iwasaki T, Ueda Y, Iwao Y, Yonezawa K, Fukami Y.

Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization.

J Biol Chem. 2005 Apr 15;280(15):15029-37. Epub 2005 Feb 7. PubMed PMID: 15699050.

36: Tokmakov A, Iwasaki T, Itakura S, Sato K, Shirouzu M, Fukami Y, Yokoyama S.

Regulation of Src kinase activity during Xenopus oocyte maturation.

Dev Biol. 2005 Feb 15;278(2):289-300. PubMed PMID: 15680350.


35: Kurokawa M, Sato K, Fissore RA.

Mammalian fertilization: from sperm factor to phospholipase Cz.

Biol Cell. 2004 Feb;96(1):37-45. Review. PubMed PMID:15093126.

34: Kurokawa M, Sato K, Smyth J, Wu H, Fukami K, Takenawa T, Fissore RA.

Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs.

Reproduction. 2004 Apr;127(4):441-54. PubMed PMID: 15047935.

33: Sato K, Iwasaki T, Hirahara S, Nishihira Y, Fukami Y.

Molecular dissection of egg fertilization signaling with the aid of tyrosine kinase-specific inhibitor and activator strategies.

Biochim Biophys Acta. 2004 Mar 11;1697(1-2):103-21. Review. PubMed PMID: 15023354.


32: Sato K, Nagao T, Iwasaki T, Nishihira Y, Fukami Y.

Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells.

Genes Cells. 2003 Dec;8(12):995-1003. PubMed PMID: 14750954.

31: Sato K, Tokmakov AA, He CL, Kurokawa M, Iwasaki T, Shirouzu M, Fissore RA, Yokoyama S, Fukami Y. Reconstitution of Src-dependent phospholipase Cg phosphorylation and transient calcium release by using membrane rafts and cell-free extracts from Xenopus eggs.

J Biol Chem. 2003 Oct 3;278(40):38413-20. Epub 2003 Jul 7. PubMed PMID: 12847104.


30: Sato K, Iwasaki T, Sakakibara K, Itakura S, Fukami Y.

Towards the molecular dissection of fertilization signaling: Our functional genomic/proteomic strategies.

Proteomics. 2002 Sep;2(9):1079-89. Review. PubMed PMID: 12362326.

29: Fukami Y, Nagao T, Iwasaki T, Sato K.

Inhibition and activation of c-Src: the head and tail of a coin.

Pharmacol Ther. 2002 Feb-Mar;93(2-3):263-70. Review. PubMed PMID: 12191618.

28: Tokmakov AA, Sato KI, Iwasaki T, Fukami Y.

Src kinase induces calcium release in Xenopus egg extracts via PLCg and IP3-dependent mechanism.

Cell Calcium. 2002 Jul;32(1):11-20. PubMed PMID: 12127058.

27: Tokmakov AA, Sato KI, Fukami Y.

The signalling cascade of fertilization.

Tsitologiia. 2002;44(3):227-34. Review. Russian. PubMed PMID: 12094760.

26: Sato K, Nagao T, Kakumoto M, Kimoto M, Otsuki T, Iwasaki T, Tokmakov AA, Owada K, Fukami Y.

Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.

J Biol Chem. 2002 Aug 16;277(33):29568-76. Epub 2002 Jun 4. PubMed PMID: 12048194.

25: Matsuoka D, Nanmori T, Sato K, Fukami Y, Kikkawa U, Yasuda T.

Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro and in vivo: analysis of active mutants expressed in E. coli and generation of the active form in stress response in seedlings.

Plant J. 2002 Mar;29(5):637-47. PubMed PMID: 11874576.

24: Sato K, Iwasaki T, Ogawa K, Konishi M, Tokmakov AA, Fukami Y.

Low density detergent-insoluble membrane of Xenopus eggs: subcellular microdomain for tyrosine kinase signaling in fertilization.

Development. 2002 Feb;129(4):885-96. PubMed PMID: 11861472.


23: Tokmakov AA, Sato KI, Fukami Y.

Calcium oscillations in Xenopus egg cycling extracts.

J Cell Biochem. 2001 Apr 2-27;82(1):89-97. PubMed PMID: 11400166.

22: Sato K, Ogawa K, Tokmakov AA, Iwasaki T, Fukami Y.

Hydrogen peroxide induces Src family tyrosine kinase-dependent activation of Xenopus eggs.

Dev Growth Differ. 2001 Feb;43(1):55-72. PubMed PMID: 11148452.


21: Sato K, Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov AA, Fukami Y.

Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.

Genes Cells. 2000 Sep;5(9):749-64. PubMed PMID: 10971656.

20: Sato K, Tokmakov AA, Iwasaki T, Fukami Y.

Tyrosine kinase-dependent activation of phospholipase Cg is required for calcium transient in Xenopus egg fertilization.

Dev Biol. 2000 Aug 15;224(2):453-69. PubMed PMID: 10926780.

19: Sato K, Tokmakov AA, Fukami Y.

Fertilization signalling and protein-tyrosine kinases.

Comp Biochem Physiol B Biochem Mol Biol. 2000 Jun;126(2):129-48. Review. PubMed PMID: 10874161.

18: Tokmakov AA, Sato KI, Fukami Y.

Deregulation of mitogen-activated protein kinase at low pH due to a structural rearrangement of activation segment.

Biochim Biophys Acta. 2000 Jan 3;1476(1):66-74. PubMed PMID: 10606768.


17: Fukami Y, Tokmakov AA, Konaka K, Sato K.

Peptide inhibitors of the mitogen-activated protein kinase pathway: a structure-mimetic peptide corresponding to the conserved inter-DFG-APE region in the kinase domain.

Pharmacol Ther. 1999 May-Jun;82(2-3):399-407. Review. PubMed PMID: 10454215.

16: Aoto M, Sato K, Takeba S, Horiuchi Y, Iwasaki T, Tokmakov AA, Fukami Y.

A 58-kDa Shc protein is present in Xenopus eggs and is phosphorylated on tyrosine residues upon egg activation.

Biochem Biophys Res Commun. 1999 May10;258(2):265-70. PubMed PMID: 10329376.

15: Sato K, Iwao Y, Fujimura T, Tamaki I, Ogawa K, Iwasaki T, Tokmakov AA, Hatano O, Fukami Y.

Evidence for the involvement of a Src-related tyrosine kinase in Xenopus egg activation.

Dev Biol. 1999 May 15;209(2):308-20. PubMed PMID:10328923.


14: Tokmakov AA, Sato K, Konaka K, Fukami Y.

Inhibition of MAPK pathway by a synthetic peptide corresponding to the activation segment of MAPK.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):214-9. PubMed PMID: 9813172.

13: Sato K, Otsuki T, Kimoto M, Kakumoto M, Tokmakov AA, Watanabe Y, Fukami Y.

c-Src and phosphatidylinositol 3-kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells.

Biochem Biophys Res Commun. 1998 Sep18;250(2):223-8. PubMed PMID: 9753611.

12: Sato K, Iwasaki T, Tamaki I, Aoto M, Tokmakov AA, Fukami Y.

Involvement of protein-tyrosine phosphorylation and dephosphorylation in sperm-induced Xenopus egg activation.

FEBS Lett. 1998 Mar 6;424(1-2):113-8. PubMed PMID: 9537526.


11: Sato K, Gotoh N, Otsuki T, Kakumoto M, Aoto M, Tokmakov AA, Shibuya M, Fukami Y.

Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src.

Biochem Biophys Res Commun. 1997 Nov 17;240(2):399-404. PubMed PMID: 9388490.

10: Tokmakov AA, Sato KI, Fukami Y.

Phosphorylation-sensitive secondary structure in a synthetic peptide corresponding to the activation loop of MAP kinase.

Biochem Biophys Res Commun. 1997 Jul 18;236(2):243-7. PubMed PMID: 9240417.

9: Sato K, Yamamoto H, Otsuki T, Aoto M, Tokmakov AA, Hayashi F, Fukami Y.

Phosphatidylinositol 4,5-bisphosphate stimulates phosphorylation of the adaptor protein Shc by c-Src.

FEBS Lett. 1997 Jun 30;410(2-3):136-40. PubMed PMID: 9237616.


8: Tokmakov AA, Sahara S, Sato K, Nishida E, Fukami Y.

Phosphoregulatory tyrosine of Xenopus mitogen-activated protein kinase is out of the reach of the enzyme catalytic center after autophosphorylation. Biochemical evidence for conformational changes upon phosphorylation.

Eur J Biochem. 1996 Oct 15;241(2):322-9. PubMed PMID: 8917426.

7: Sato K, Aoto M, Mori K, Akasofu S, Tokmakov AA, Sahara S, Fukami Y.

Purification and characterization of a Src-related p57 protein-tyrosine kinase from Xenopus oocytes. Isolation of an inactive form of the enzyme and its activation and translocation upon fertilization.

J Biol Chem. 1996 May 31;271(22):13250-7. PubMed PMID: 8662722.

6: Sahara S, Sato K, Kaise H, Mori K, Sato A, Aoto M, Tokmakov AA, Fukami Y.

Biochemical evidence for the interaction of regulatory subunit of cAMP-dependent protein kinase with IDA (Inter-DFG-APE) region of catalytic subunit.

FEBS Lett.1996 Apr 15;384(2):138-42. PubMed PMID: 8612810.


5: Sato K, Sato A, Aoto M, Fukami Y.

c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.

Biochem Biophys Res Commun. 1995 Oct 24;215(3):1078-87. PubMed PMID: 7488034.

4: Sato K, Sato A, Aoto M, Fukami Y.

Site-specific association of c-Src with epidermal growth factor receptor in A431 cells.

Biochem Biophys Res Commun. 1995 May 25;210(3):844-51. PubMed PMID: 7539262.


3: Fukami Y, Sato K, Ikeda K, Kamisango K, Koizumi K, Matsuno T.

Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site.

J Biol Chem. 1993 Jan 15;268(2):1132-40. PubMed PMID: 7678249.


2: Sahara S, Sato K, Aoto M, Ohnishi T, Kaise H, Koide H, Ogita K, Fukami Y.

Characterization of protein kinase C in Xenopus oocytes.

Biochem Biophys Res Commun. 1992 Jan 15;182(1):105-14. PubMed PMID: 1310011.


1: Sato K, Miki S, Tachibana H, Hayashi F, Akiyama T, Fukami Y.

A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases.

Biochem Biophys Res Commun. 1990 Sep 28;171(3):1152-9. PubMed PMID: 2171508.

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CSD Lab: Publications