Original Articles

2016

1. Chanmee, T., Ontong, P., Izumikawa,T., Higashide,M., Mochizuki, N., Chokchaitaweesuk,C., Khansai,M., Nakajima,K., Kakizaki,I., Kongtawelert, P., *Taniguchi,N., and *Itano N. Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling. J. Biol. Chem.291(46):24105-24120. 2016.

2014

2. Chanmee, T., Ontong, P., Mochizuki, N., Kongtawelert, P., *Konno, K., and *Itano N. Excessive Hyaluronan Production Promotes Acquisition of Cancer Stem Cell Signatures Through the Coordinated Regulation of Twist and the TGF-β-Snail Signaling Axis. J. Biol. Chem. 289(38):26038-26056. 2014.
3. Arranz, A.M., Perkins, K.L., Irie, F., Lewis, D.P., Hrabe, J., Xiao, F., Itano, N., Kimata, K., Hrabetova, S., and *Yamaguchi, Y. Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J. Neurosci. 34(18):6164-6176. 2014.
4. *Konno, K., Shiotani, Y., Itano, N., Ogawa, T., Hatakeyama, M., Shioya, K., Kasai, N. Visible, safe and certain endotracheal intubation using endoscope system and inhalation anesthesia for rats. J. Vet. Med. Sci. 76(10):1375-1381. 2014.
5. *Konno, K., Itano, N., Ogawa, T., Hatakeyama, M., Shioya, K., and Kasai, N. New visible endotracheal intubation method using the endoscope system for mice inhalational anesthesia. J. Vet. Med. Sci. 76(6):863-868. 2014.
6. Ontong, P., Hatada, Y., Taniguchi, S., Kakizaki, I., and *Itano, N. Effect of a cholesterol-rich lipid environment on the enzymatic activity of reconstituted hyaluronan synthase. Biochem. Biophys. Res. Commun. 443: 666-671. 2014.

2013

7. Kashima, Y., Takahashi, M., Shiba, Y., Itano, N., Izawa, A., Koyama, J., Nakayama, J., Taniguchi, S., Kimata, K., and *Ikeda, U. Crucial role of hyaluronan in neointimal formation after vascular injury. PLoS One. 8(3):e58760. 2013.
8. Ikuta, T., Kobayashi, Y., Kitazawa, M., Shiizaki, K., Itano, N., Noda, T., Pettersson, S., Poellinger, L., Fujii-Kuriyama, Y., Taniguchi, S., and Kawajiri, K. ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. Carcinogenesis. 34(7):1620-1627. 2013.

2012

9. Goncharova, V., Serobyan, N., Iizuka, S., Schraufstatter, I., de Ridder, A., Povaliy, T., Wacker, V., Itano, N., Kimata, K., Orlovskaja, I.A., Yamaguchi, Y., and *Khaldoyanidi, S. Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis. J. Biol. Chem. 287(30):25419-25433, 2012.
10. Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., and *Tanaka, S. Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. Biol. Pharm. Bull. 35(3):408-412, 2012.
11. Mack, J.A., Feldman, R.J., Itano, N., Kimata, K., Lauer, M., Hascall, V.C., and *Maytin, E.V. Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3. J. Invest. Dermatol. 132(1):198-207, 2012.

2011

12. Yabushita, H., Iwasaki, K., Kanyama, K., Obayashi, Y., Zhuo, L., Itano, N., Kimata, K., Wakatsuki, A. Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer. Obstet. Gynecol. Int. 2011:739150, 2011
13. Yamazaki, H., Takeoka, M., Kitazawa, M., Ehara, T., Itano, N., Kato, H., and *Taniguchi, S. ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis.　Rheumatol Int. 10, 2011.

2010

14. Kobayashi, N., Miyoshi, S., Mikami, T., Koyama, H., Kitazawa, M., Takeoka, M., Sano, K., Amano, J., Isogai, Z., Niida, S., Oguri, K., Okayama, M., McDonald, JA., Kimata, K., Taniguchi, S., and *Itano, N. Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res. 70(18):7073-7083, 2010.
15. Nakajima, K., Takeoka, M., Mori, M., Hashimoto, S., Sakurai, A., Nose, H., Higuchi, K., Itano, N., Shiohara, M., Oh, T., and Taniguchi, S. Exercise effects on methylation of ASC gene. Int. J. Sports Med. 31(9):671-675, 2010.
16. Sugaya, A., Takeoka, M., Itano, N., Taguchi, A., Ehara, T, and *Taniguchi, S. Calponin h1-S175T point mutation enhances resistance to actin cytoskeleton perturbation in human cancer cells. Anticancer Res. 30(4):1071-1078, 2010.
17. Kanayama, K., Yabushita, H., Obayashi, Y., Noguchi, M., Zhuo, L., Itano, N., Kimata, K., and *Wakatsuki, A., Role of hyaluronan synthase, hyaluronan and serum-derived hyaluronan-associated protein (SHAP)-hyaluronan complex in endometrial cancer. J. Aichi Med. Univ. Assoc. 38(1-4):29-42, 2010.

2009

18. Hirayama, Y., Yoshimura, M., Ozeki, Y., Sugawara, I., Udagawa, T., Mizuno, S., Itano, N., Kimata, K., Tamaru, A., Ogura, H., Kobayashi, K., *Matsumoto, S. Mycobacteria exploit host hyaluronan for efficient extracellular replication. PLoS Pathog. 5; e1000643. 2009.
19. Matsushita, K., Takeoka, M., Sagara, J., Itano, N., Kurose, Y., Nakamura, A., *Taniguchi, S. A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC. Mediators Inflamm. 2009:287387. 2009.
20. Benoit, B.N., Kobayashi, M., Kawakubo, M., Takeoka, M., Zou, J., Itano, N., Tsutsui, H., Noda, T., Fukuda, M., Nakayama, J., and Taniguchi, S. Role of ASC in the mouse model of Helicobacter pylori infection. J. Histochem. Cytochem. 57:327-338. 2009.
21. Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K., Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., and *Tanaka, S. Involvement of CD44 in mast cell proliferation during terminal differentiation. Lab. Invest. 89:446-455. 2009

2008

22. Koyama, H., Kobayashi, N., Harada, M., Takeoka, M., Kawai, Y., Sano, K., Fujimori, M., Amano, J., Ohhashi, T., Kannagi, R., Kimata, K., Taniguchi, S., and *Itano, N. Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment. Am. J. Pathol. 172:179-193. 2008.
23. Kakizaki, I., Itano, N., Kimata, K., Hanada, K., Kon, A., Yamaguchi, M., Takahashi, T., and *Takagaki, K. Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation. Arch. Biochem. Biophys. 471:85-93. 2008.
24. Yanagisawa, Y., Takeoka, M., Ehara, T., Itano, N., Miyagawa, S., and *Taniguchi, S. Reduction of Calponin h1 expression in human colon cancer blood vessels. Eur. J. Surg. Oncol.34:531-537. 2008.

2007

25. Koyama, H., Hibi, T., Isogai, Z., Yoneda, M., Fujimori, M., Amano, J., Kawakubo, M., Kannagi, R., Kimata, K., Taniguchi, S., and *Itano, N. Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Accelerates Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican /PG-M. Am. J. Pathol. 170:1086-1099, 2007
26. Sakai, A., *Akifusa, S., Itano, N., Kimata, K., Kawamura, T., Koseki, T., Takehara, T., and Nishihara, T. Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells. Med Mycol. 45:73-79, 2007.
27. Hasegawa, K., Yoneda, M., Kuwabara, H., Miyaishi, O., Itano, N., Ohno, A., Zako, M., and *Isogai, Z. Versican, a Major Hyaluronan-Binding Component in the Dermis, Loses its Hyaluronan-Binding Ability in Solar Elastosis. J. Invest. Dermatol. 127:1657-1663. 2007.

2006

28. Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., *Kimata, K. SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum. J. Biol. Chem. 281:20303-20314, 2006.

2005

29. Kanomata, N., Yokose, T., Kamijo, T., Yonou, H., Hasebe, T., Itano, N., Kimata, K., and *Ochiai, A. Hyaluronan synthase expression in pleural malignant mesotheliomas. Virchows Arch. 446:246-250, 2005.
30. Yabushita, H., Kishida, T., Fusano, K., Kanyama, K., Zhuo, L., Itano, N., Kimata, K., and *Noguchi, M. Role of hyaluronan and hyaluronan synthase in endometrial cancer. Oncol Rep.13:1101-1105, 2005.
31. Sawai, T., Itano, N., and *Kimata, K. Transcriptional regulation of hyaluronan synthases by bone morphogenetic protein-2 in mouse mammary chondrocytes. J. Aichi Med. Univ. Assoc.33:1-6, 2005.

2004

32. *Yoshida, M., Sai, S., Marumo, K., Tanaka, T., Itano, N., Kimata, K., and Fujii, K.　Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction. Arthritis Res. & Therapy 6:R514-R520, 2004
33. Kakizaki, I., Kojima, K., Takagaki, K., Endo, M., Kannagi, R., Ito, M., Maruo, Y., Sato, H., Yasuda, T., Mita, S., Kimata, K., and *Itano, N. A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone. J Biol Chem.279:33281-33289, 2004.
34. Yabushita, H., Noguchi, M., Kishida, T., Fusano, K., Noguchi, Y., Itano, N., Kimata, K., and *Noguchi, M. Hyaluronan synthase expression in ovarian cancer. Oncol Rep.12:739-743, 2004.
35. Takeo, S., Fujise, M., Akiyama, T., Habuchi, H., Itano, N., Matsuo, T., Aigaki, T., Kimata, K., and *Nakato, H. In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila. J Biol Chem.279:18920-18925, 2004.
36. *Itano, N., Sawai, T., Atsumi, F., Miyaishi, O., Taniguchi, S., Kannagi, R., Hamaguchi, M., and Kimata, K. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. J Biol Chem.279:18679-18687, 2004.
37. *Yamada, Y., Itano, N., Hata, K., Ueda, M., and Kimata, K. Differential regulation by IL-1b and EGF of expression of three different hyaluronan synthases in oral mucodal epithelial cells and fibroblasts and dermal fibroblasts: quantitative analysis using real time RT-PCR. J Invest Dermatol.122:631-639, 2004.
38. Yamada, Y., *Itano, N., Narimatsu, H., Kudo, T., Morozumi, K., Hirohashi, S., Ochiai, A., Ueda, M., and Kimata, K. Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer Clin. Exp. Metastasis 21:57-63, 2004.

2003

39. *Yamada, Y., Itano, N., Narimatsu, H. Takashi K., Hirohashi, S., Ochiai, A., Ueda, M., and Kimata, K. 2003. CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction. Oncol. Rep. 10: 1919-1924, 2003
40. Itano, N., Okamoto, S., Zhang, D., Lipton, S.A., and *Ruoslahti, E. Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A.100: 5181-5186, 2003.

2002

41. *Itano, N., Atsumi, F., Sawai, T., Yamada, Y., Miyaishi, O., Senga, T., Hamaguchi, M., and Kimata, K. Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proc Natl Acad Sci U S A 99:3609-3614, 2002
42. Munesue, S., Kusano, Y., Oguri, K., Itano, N., Yoshitomi, Y., Nakanishi, H., Yamashina, I., and *Okayama, M. The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones. Biochem J 363:201-209, 2002

2000

43. Yoshida, M., Itano, N., Yamada, Y., and *Kimata, K. In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity. J. Biol. Chem. 275:497-506, 2000

1999

44. Ichikawa, T., Itano, N., Sawai, T., Kimata, K., Koganehira, Y., Saida, T., and *Taniguchi, S. Increased synthesis of hyaluronate enhances motility of human melanoma cells. J Invest Dermatol. 113:935-939, 1999.
45. *Itano, N., Sawai, T., Miyaishi, O., and Kimata, K. Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells. Cancer Res. 59:2499-2504, 1999.
46. Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M., Shinomura, T., Hamaguchi, M., Yoshida, Y., Ohnuki, Y., Miyauchi, S., Spicer, A.P., McDonald, J.A. and *Kimata, K. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem.274: 25085-25092, 1999.
47. Takada, Y., *Sakiyama, H., Kuriiwa, K., Masuda, R., Inoue, N., Nakagawa, K. Itano, N., Saito, T., Yamada, T., and Kimata, K. Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases Cell. Tissue Res. 298:317-325, 1999.
48. Yamada, Y., Itano, N., Narimatsu, H., Kudo, T., Hirohashi, S., Ochiai, A., Niimi,., A., Ueda, M., and *Kimata, K. Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction. Jpn J Cancer Res 90:987-992, 1999

1998

49. Yamada, Y., Itano, N., Zako, M., Yoshida, M., Lenas, P., Niimi, A., Ueda, M., and *Kimata, K. The gene structure and promoter sequence of mouse hyaluronan synthase 1. Biochem. J. 330 ( Pt 3):1223-1227, 1998

1997

50. Isogai, Z., Yoneda, M., Itano, N., and *Kamata, K. Altered expression hyaluronan-rich matrices composed of PG-M/versican, SHAP and hyaluronan in solar elastosis. Nagoya Med. J. 41:27-37, 1997.
51. Sawai, T., *Usui, N., Sando, K., Fukui, Y., Kamata, S., Okada, A., Taniguchi, N., Itano, N., and Kimata, K. Hyaluronic acid of wound fluid in adult and fetal rabbits. J. Pediatr. Surg. 32:41-43, 1997.
52. Spicer, A.P., Seldin, M.F., Olsen, A.S., Brown, N., Wells, D.E., Doggett, N.A., Itano, N., Kimata, K., Inazawa, J., and *McDonald, J.A. Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics41:493-497, 1997.
53. Watanabe, H., Cheung, S.C., Itano, N., Kimata, K., and *Yamada, Y. Identification of hyaluronan-binding domains of aggrecan. J. Biol. Chem. 272:28057-28065, 1997.

1996

54. Itano, N., and *Kimata, K. Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase. J. Biol. Chem. 271:9875-9878, 1996.
55. Itano, N., and *Kimata, K. Molecular cloning of human hyaluronan synthase. Biochem. Biophys. Res. Commun. 222:816-820, 1996.
56. Itano, N., Oguri, K., Nagayasu, Y., Kusano, Y., Nakanishi, H., David, G., and *Okayama, M. Phosphorylation of a membrane-intercalated proteoglycan, syndecan-2, expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma. Biochem. J. 315:925-930, 1996.

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